US 12,283,046 B2
Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking
James K. Min, Denver, CO (US); James P. Earls, Fairfax Station, VA (US); Hugo Miguel Rodrigues Marques, Lisbon (PT); Shant Malkasian, Pasadena, CA (US); and Ben Hootnick, New York, NY (US)
Assigned to CLEERLY, INC., Denver, CO (US)
Filed by CLEERLY, INC., Denver, CO (US)
Filed on Feb. 23, 2024, as Appl. No. 18/586,224.
Application 18/586,224 is a continuation of application No. 18/148,995, filed on Dec. 30, 2022, granted, now 11,967,078.
Application 18/148,995 is a continuation of application No. 17/820,439, filed on Aug. 17, 2022.
Application 17/820,439 is a continuation in part of application No. 17/662,734, filed on May 10, 2022, granted, now 11,751,826, issued on Sep. 12, 2023.
Application 17/662,734 is a continuation of application No. 17/367,549, filed on Jul. 5, 2021, granted, now 11,367,190, issued on Jun. 21, 2022.
Application 17/367,549 is a continuation of application No. 17/350,836, filed on Jun. 17, 2021, granted, now 11,969,280.
Application 17/350,836 is a continuation in part of application No. 17/213,966, filed on Mar. 26, 2021, granted, now 11,094,060, issued on Aug. 17, 2021.
Application 17/213,966 is a continuation of application No. 17/142,120, filed on Jan. 5, 2021, granted, now 11,501,436, issued on Nov. 15, 2022.
Claims priority of provisional application 63/296,116, filed on Jan. 3, 2022.
Claims priority of provisional application 63/264,913, filed on Dec. 3, 2021.
Claims priority of provisional application 63/264,805, filed on Dec. 2, 2021.
Claims priority of provisional application 63/276,268, filed on Nov. 5, 2021.
Claims priority of provisional application 63/241,427, filed on Sep. 7, 2021.
Claims priority of provisional application 63/235,010, filed on Aug. 19, 2021.
Claims priority of provisional application 63/201,142, filed on Apr. 14, 2021.
Claims priority of provisional application 63/142,873, filed on Jan. 28, 2021.
Claims priority of provisional application 63/089,790, filed on Oct. 9, 2020.
Claims priority of provisional application 63/077,044, filed on Sep. 11, 2020.
Claims priority of provisional application 63/077,058, filed on Sep. 11, 2020.
Claims priority of provisional application 63/041,252, filed on Jun. 19, 2020.
Claims priority of provisional application 62/958,032, filed on Jan. 7, 2020.
Prior Publication US 2024/0193776 A1, Jun. 13, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. G06T 7/00 (2017.01); A61B 5/00 (2006.01); A61B 5/055 (2006.01); A61B 6/00 (2006.01); A61B 6/03 (2006.01); A61B 6/50 (2024.01); A61B 8/12 (2006.01); A61B 8/14 (2006.01); A61K 49/04 (2006.01)
CPC G06T 7/0012 (2013.01) [A61B 5/0066 (2013.01); A61B 5/0075 (2013.01); A61B 5/055 (2013.01); A61B 5/7267 (2013.01); A61B 5/742 (2013.01); A61B 5/7475 (2013.01); A61B 6/032 (2013.01); A61B 6/037 (2013.01); A61B 6/481 (2013.01); A61B 6/504 (2013.01); A61B 6/5205 (2013.01); A61B 8/12 (2013.01); A61B 8/14 (2013.01); A61K 49/04 (2013.01); G06T 2207/10081 (2013.01); G06T 2207/10088 (2013.01); G06T 2207/10101 (2013.01); G06T 2207/10132 (2013.01); G06T 2207/20081 (2013.01); G06T 2207/30048 (2013.01); G06T 2207/30101 (2013.01)] 25 Claims
OG exemplary drawing
 
1. A computer-implemented method for guiding determination of treatment for a subject with coronary artery disease (CAD) based on CAD risk staging derived from non-invasive medical image analysis, the method comprising:
accessing, by a computer system, a CAD risk factor level for a subject;
accessing, by the computer system, a medical image of the subject, the medical image comprising one or more coronary arteries;
analyzing, by the computer system, the medical image of the subject to determine a CAD risk stage for the subject, the CAD risk stage comprising a risk assessment based at least in part on vascular morphology and quantitative phenotyping of atherosclerosis comprising analysis of one or more of plaque volume, plaque composition, or plaque progression, wherein a CAD risk stage above a predetermined CAD risk stage threshold is indicative of a need for treatment of CAD for the subject;
determining, by the computer system, correlation of the CAD risk factor level with the CAD risk stage; and
determining, by the computer system, a subject-specific goal for the CAD risk factor level based at least in part on the determined correlation of the CAD risk factor level with the CAD risk stage, wherein the determined subject-specific goal for the CAD risk factor level is configured to be used to determine an individualized treatment for the subject, wherein the computer system comprises a computer processor and an electronic storage medium.