US 12,282,079 B2
Determination of a subject specific hemodynamic response function
Rudolf Mathias Johannes Nicolaas Lamerichs, Liempde (NL); Timmy Robertus Maria Leufkens, Upplands Vasby (SE); and Joanne Henriette Desirée Monique Westerink, Eindhoven (NL)
Assigned to Koninklijke Philips N.V., Eindhoven (NL)
Appl. No. 18/692,096
Filed by KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
PCT Filed Sep. 1, 2022, PCT No. PCT/EP2022/074297
§ 371(c)(1), (2) Date Mar. 14, 2024,
PCT Pub. No. WO2023/041339, PCT Pub. Date Mar. 23, 2023.
Claims priority of application No. 21197367 (EP), filed on Sep. 17, 2021.
Prior Publication US 2024/0272257 A1, Aug. 15, 2024
Int. Cl. G01R 33/48 (2006.01); A61B 5/055 (2006.01); G01R 33/50 (2006.01); G01R 33/565 (2006.01)
CPC G01R 33/4806 (2013.01) [A61B 5/055 (2013.01); G01R 33/50 (2013.01); G01R 33/56554 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A medical system comprising:
a memory storing machine executable instructions;
a computational system, wherein execution of the machine executable instructions causes the computational system to:
receive a time series of a R2-star map for a brain volume of a subject;
receive a stimulus signal descriptive of an occurrence of a sensory stimulus repeatedly provided to the subject, wherein the stimulus signal is synchronized to the time series of the R2-star map;
receive a selection of one or more seed voxels identified in the time series of the R2-star map;
calculate a denoised time series of the R2-star map by applying a temporal filter algorithm to the time series of the R2-star map;
calculate a correlation map for each voxel of the one or more seed voxels by calculating a pixel wise correlation between each voxel of the one or more seed voxels in the time series of the R2-star map and the denoised time series of the R2-star map;
determine an activated region of the brain volume by combining voxels identified in the correlation map for each voxel of the one or more seed voxels above a predetermined threshold;
provide a hemodynamic response function for each voxel and each occurrence of the sensory stimulus in the activated region of the brain volume by aligning the time series of the R2-star map with the stimulus signal; and
provide a subject specific hemodynamic response function by averaging the hemodynamic response function for each voxel and each occurrence of the sensory stimulus in the activated region of the brain volume.