	US 12,282,028 B2
	Atomic description of immune complex that causes heparin-induced thrombocytopenia
Mark I. Greene, Penn Valley, PA (US); Douglas B. Cines, Wynnewood, PA (US); Zheng Cai, Wynnewood, PA (US); and Zhiqiang Zhu, Philadelphia, PA (US)
Assigned to The Trustees of the University of Pennsylvania, Philadelphia, PA (US)
Filed by The Trustees of the University of Pennsylvania, Philadelphia, PA (US)
Filed on Jan. 23, 2024, as Appl. No. 18/420,177.
Application 18/420,177 is a continuation of application No. 17/929,524, filed on Sep. 2, 2022, granted, now 11,913,963.
Application 17/929,524 is a continuation of application No. 16/446,902, filed on Jun. 20, 2019, granted, now 11,435,362, issued on Sep. 6, 2022.
Application 16/446,902 is a continuation of application No. 15/524,511, granted, now 10,371,705, issued on Aug. 6, 2019, previously published as PCT/US2015/059283, filed on Nov. 5, 2015.
Claims priority of provisional application 62/221,485, filed on Sep. 21, 2015.
Claims priority of provisional application 62/076,213, filed on Nov. 6, 2014.
Prior Publication US 2024/0241132 A1, Jul. 18, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 33/577 (2006.01); A61K 38/19 (2006.01); A61K 39/395 (2006.01); C07K 14/52 (2006.01); C07K 16/18 (2006.01); C07K 16/24 (2006.01); G01N 33/53 (2006.01); G01N 33/68 (2006.01); G01N 33/86 (2006.01); A61K 39/00 (2006.01)

CPC G01N 33/6863 (2013.01) [A61K 38/195 (2013.01); A61K 39/3955 (2013.01); C07K 14/522 (2013.01); C07K 16/24 (2013.01); G01N 33/86 (2013.01); A61K 2039/505 (2013.01); G01N 2333/522 (2013.01); G01N 2400/40 (2013.01); G01N 2800/222 (2013.01); G01N 2800/50 (2013.01); G01N 2800/52 (2013.01)]

5 Claims

1. A mutant platelet factor 4 (PF4) monomer comprising amino acids 9 to 70 of SEQ ID NO: 11 and having a Q9S substitution relative to the amino acid sequence of SEQ ID NO: 11.