US 12,282,000 B2
Biological sample analysis device and biological sample analysis method
Ayaka Okuno, Tokyo (JP); Michiru Fujioka, Tokyo (JP); and Toru Yokoyama, Tokyo (JP)
Assigned to Hitachi High-Tech Corporation, Tokyo (JP)
Appl. No. 17/761,453
Filed by Hitachi High-Tech Corporation, Tokyo (JP)
PCT Filed Sep. 17, 2019, PCT No. PCT/JP2019/036364
§ 371(c)(1), (2) Date Mar. 17, 2022,
PCT Pub. No. WO2021/053713, PCT Pub. Date Mar. 25, 2021.
Prior Publication US 2022/0326179 A1, Oct. 13, 2022
Int. Cl. G01N 27/447 (2006.01); G01N 27/453 (2006.01); G01N 30/86 (2006.01)
CPC G01N 27/44721 (2013.01) [G01N 30/8631 (2013.01)] 14 Claims
OG exemplary drawing
 
13. A biological sample analysis method which analyzes a biological sample by using electrophoresis, comprising:
a measuring step of measuring the biological sample while electrophoresis a sample containing the biological sample; and
a computing step of generating measurement data descriptive of a result of the measurement in the measuring step,
wherein the biological sample is given two or more types of fluorescent labels different from each other,
wherein in the computing step, first measurement data descriptive of a measurement result obtained by measuring a first sample containing the biological sample while electrophoresis the first sample is generated,
wherein in the computing step, second measurement data descriptive of a measurement result obtained by measuring a second sample containing a reference sample having a reference value serving as a basis for quantifying the biological sample while electrophoresis the second sample is generated, and
wherein in the computing step, a difference between the first measurement data and the second measurement data is compared with a threshold value to thereby determine whether or not it is necessary to reacquire the reference value for quantifying the biological sample by remeasuring the second sample to obtain a third measurement data that replaces the second measurement data before the biological sample is remeasured.