US 12,281,986 B2
Multi-track Raman well plate reader
Nicolas Vezard, Edison, NJ (US); Beth Finamore, Rahway, NJ (US); and Aashish Tuladhar, Piscataway, NJ (US)
Assigned to Horiba Instruments Incorporated, Irvine, CA (US)
Filed by HORIBA INSTRUMENTS INCORPORATED, Irvine, CA (US)
Filed on Dec. 22, 2022, as Appl. No. 18/087,341.
Claims priority of provisional application 63/293,733, filed on Dec. 24, 2021.
Prior Publication US 2023/0204515 A1, Jun. 29, 2023
Int. Cl. G01N 21/65 (2006.01); G01N 21/64 (2006.01)
CPC G01N 21/65 (2013.01) [G01N 21/6428 (2013.01); G01N 2201/06113 (2013.01); G01N 2201/0633 (2013.01); G01N 2201/0635 (2013.01); G01N 2201/0636 (2013.01); G01N 2201/08 (2013.01); G01N 2201/127 (2013.01)] 50 Claims
OG exemplary drawing
 
1. A system for obtaining Raman spectra from liquid samples within an array of sample holders, the system comprising:
at least one laser;
at least two Raman probes each positioned perpendicular to the array of sample holders and aligned to simultaneously acquire Raman spectra of the liquid samples in non-adjacent sample holders, each Raman probe including an input optically coupled to the at least one laser, and a sample lens configured to receive light from the input, to focus the light from the input within an associated liquid sample, to collect light from the associated liquid sample, and to direct the collected light from the associated liquid sample to an output;
a spectrometer optically coupled to the outputs of the at least two Raman probes, the spectrometer including a diffraction grating configured to direct light collected by the Raman probes to a sensor;
a mechanical positioning mechanism configured to adjust a relative position between the array of sample holders and the at least two Raman probes; and
at least one controller in communication with the at least one laser, the spectrometer, and the mechanical positioning mechanism, the at least one controller programmed to generate Raman spectra based on signals from the sensor of the spectrometer for the liquid samples of the at least two non-adjacent sample holders, and control the positioning mechanism to change position of the at least two Raman probes relative to the array of sample holders to simultaneously acquire Raman spectra of the liquid samples in different non-adjacent sample holders of the array.