US 12,281,338 B2
Nucleobase editors comprising GeoCas9 and uses thereof
David R. Liu, Cambridge, MA (US); and Yongjoo Kim, Cambridge, MA (US)
Assigned to The Broad Institute, Inc., Cambridge, MA (US); and President and Fellows of Harvard College, Cambridge, MA (US)
Appl. No. 17/289,665
Filed by The Broad Institute, Inc., Cambridge, MA (US); and President and Fellows of Harvard College, Cambridge, MA (US)
PCT Filed Oct. 29, 2019, PCT No. PCT/US2019/058678
§ 371(c)(1), (2) Date Apr. 28, 2021,
PCT Pub. No. WO2020/092453, PCT Pub. Date May 7, 2020.
Claims priority of provisional application 62/752,225, filed on Oct. 29, 2018.
Prior Publication US 2022/0389395 A1, Dec. 8, 2022
Int. Cl. C12N 9/22 (2006.01); C12N 9/24 (2006.01); C12N 9/78 (2006.01)
CPC C12N 9/22 (2013.01) [C12N 9/2497 (2013.01); C12N 9/78 (2013.01); C12Y 305/04004 (2013.01); C12Y 305/04005 (2013.01)] 19 Claims
 
1. A fusion protein comprising an amino acid sequence that is at least 85% identical to the amino acid sequence of any one of SEQ ID NOs: 80-81.