US 12,281,205 B2
Modified antibacterial compositions and methods
Greg GuangHua Qiao, Melbourne (AU); Neil Martin O'Brien-Simpson, Melbourne (AU); Shu Jie Lam, Melbourne (AU); Anton Richard Blencowe, Melbourne (AU); and Eric Charles Reynolds, Melbourne (AU)
Assigned to The University of Melbourne, Melbourne (AU)
Appl. No. 16/343,218
Filed by The University of Melbourne, Melbourne (AU)
PCT Filed Nov. 2, 2017, PCT No. PCT/AU2017/051207
§ 371(c)(1), (2) Date Apr. 18, 2019,
PCT Pub. No. WO2018/081862, PCT Pub. Date May 11, 2018.
Claims priority of application No. PCT/AU2016/051037 (WO), filed on Nov. 2, 2016.
Prior Publication US 2020/0123328 A1, Apr. 23, 2020
Int. Cl. A61K 9/00 (2006.01); A61P 31/04 (2006.01); C08G 69/10 (2006.01); C08G 73/02 (2006.01); C08G 83/00 (2006.01)
CPC C08G 83/003 (2013.01) [A61P 31/04 (2018.01); C08G 69/10 (2013.01); C08G 73/028 (2013.01)] 27 Claims
OG exemplary drawing
 
1. A star shaped peptide polymer comprising a multifunctional core with a plurality of linear arms extending therefrom, wherein the linear arms are random peptide copolymers of at least a cationic amino acid residue and a hydrophobic amino acid residue, wherein the cationic amino acid residue and the hydrophobic amino acid residue are arranged as follows:
([Cationic Amino Acid]a-ran-[Hydrophobic Amino Acid]b)m
wherein ‘m’ represents the number of linear arms and is 2n, wherein n is a number including or between 2 and 8, ‘a’ and ‘b’ represent the number of repeat units of the amino acids in the peptide copolymer respectively and ‘ran’ refers to the random copolymerisation of the amino acids, wherein the copolymer has a molar ratio of cationic amino acid residue to hydrophobic amino acid residue of from about 1.5:1 to about 3.5:1, and wherein the copolymer exhibits a degree of polymerisation of at least 5 and up to 50 on each linear arm.