US 12,281,169 B2
Antibodies that bind to OX40 and their uses
Antoine Attinger, La Chaux-de Fonds (CH); Stanislas Blein, La Chaux-de-Fonds (CH); Jonathan Albert Back, La Chaux-de-Fonds (CH); Rami Lissilaa, La Chaux-de-Fonds (CH); and Samuel Hou, La Chaux-de-Fonds (CH)
Assigned to Ichnos Sciences SA, La Chaux-de-Fonds (CH)
Filed by Ichnos Sciences SA, La Chaux-de-Fonds (CH)
Filed on Jun. 30, 2022, as Appl. No. 17/854,904.
Application 17/854,904 is a division of application No. 16/298,289, filed on Mar. 11, 2019, granted, now 11,407,839.
Application 16/298,289 is a continuation of application No. 15/348,774, filed on Nov. 10, 2016, abandoned.
Application 15/348,774 is a continuation of application No. 14/222,421, filed on Mar. 21, 2014, abandoned.
Application 14/222,421 is a continuation of application No. 13/545,708, filed on Jul. 10, 2012, granted, now 8,748,585, issued on Jun. 10, 2014.
Claims priority of provisional application 61/506,491, filed on Jul. 11, 2011.
Prior Publication US 2022/0411526 A1, Dec. 29, 2022
Int. Cl. C07K 16/28 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01)
CPC C07K 16/2878 (2013.01) [A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/41 (2013.01); C07K 2317/52 (2013.01); C07K 2317/53 (2013.01); C07K 2317/73 (2013.01); C07K 2317/732 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); G01N 2333/70578 (2013.01)] 28 Claims
 
1. An antagonistic antibody or fragment thereof that binds to human OX40, wherein said antibody or fragment thereof comprises:
a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO: 1, a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO: 2, and a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO: 3; and
a light chain CDR1 comprising the amino acid sequence of SEQ ID NO: 4, a light chain CDR2 comprising the amino acid sequence of SEQ ID NO: 5 and a light chain CDR3 comprising the amino acid sequence of SEQ ID NO: 6.