US 12,281,121 B2
N-containing heteroaryl derivative and pharmaceutical composition comprising same as active ingredient for prevention or treatment of cancer
Seo Hyun Jo, Seoul (KR); Hua Li, Incheon (KR); Hee Sun Ryu, Incheon (KR); Hwan Kim, Seoul (KR); Ji Yoon Seok, Incheon (KR); Sun Hwa Lee, Incheon (KR); Jung Beom Son, Incheon (KR); and Nam Doo Kim, Incheon (KR)
Assigned to VORONOI Inc., Incheon (KR); and VORONOIBIO Inc., Incheon (KR)
Appl. No. 17/612,757
Filed by VORONOI Inc., Incheon (KR); and VORONOIBIO Inc., Incheon (KR)
PCT Filed May 21, 2020, PCT No. PCT/KR2020/006648
§ 371(c)(1), (2) Date Nov. 19, 2021,
PCT Pub. No. WO2020/235945, PCT Pub. Date Nov. 26, 2020.
Claims priority of application No. 10-2019-0059476 (KR), filed on May 21, 2019.
Prior Publication US 2022/0324874 A1, Oct. 13, 2022
Int. Cl. C07D 487/08 (2006.01); A61P 35/00 (2006.01); C07D 401/14 (2006.01); C07D 519/00 (2006.01)
CPC C07D 487/08 (2013.01) [A61P 35/00 (2018.01); C07D 401/14 (2013.01); C07D 519/00 (2013.01)] 8 Claims
 
1. A compound of the following Chemical Formula 1, a stereoisomer thereof, a solvate thereof, a hydrate thereof, or a pharmaceutically acceptable salt thereof:

OG Complex Work Unit Chemistry
wherein

OG Complex Work Unit Chemistry
 is furan, thiophene, benzene, or cyclopentene,
R1 is a straight or branched C1-C3 alkyl, wherein R1 is unsubstituted or substituted with at least one halogen,
Ring B is diazabicycloheptane, piperazine, diazepane, or diazaspirooctane, wherein Ring B is unsubstituted or substituted with at least one straight or branched C1-C6 alkyl,
R2 is pyridinyl, thiazolyl, phenyl, imidazolyl, pyrazinyl, quinolinyl, pyrimidinyl, or pyridonyl, wherein R2 is unsubstituted or substituted with at least one R3, and
R3 is at least one substituent selected from the group consisting of a straight or branched C1-C6 alkyl, a straight or branched C1-C6 haloalkyl, a straight or branched C1-C6 alkoxy, a halogen, a C1-C3 alkanesulfonamido, an amino substituted with at least one straight or branched C1-C3 alkyl, and nitrile.