US 12,281,097 B2
Isoquinolin-3-yl carboxamides and preparation and use thereof
Sunil Kumar KC, San Diego, CA (US); Chi Ching Mak, San Diego, CA (US); Brian Walter Eastman, San Diego, CA (US); Jianguo Cao, San Diego, CA (US); Venkataiah Bollu, San Diego, CA (US); Gopi Kumar Mittapalli, San Diego, CA (US); and Chandramouli Chiruta, San Diego, CA (US)
Assigned to BioSplice Therapeutics, Inc., San Diego, CA (US)
Filed by Biosplice Therapeutics, Inc., San Diego, CA (US)
Filed on Nov. 18, 2022, as Appl. No. 17/990,133.
Application 17/990,133 is a continuation of application No. 17/155,577, filed on Jan. 22, 2021, granted, now 11,548,872.
Application 17/155,577 is a continuation of application No. 16/703,321, filed on Dec. 4, 2019, granted, now 10,947,217, issued on Mar. 16, 2021.
Application 16/703,321 is a continuation of application No. 16/130,842, filed on Sep. 13, 2018, granted, now 10,544,128, issued on Jan. 28, 2020.
Application 16/130,842 is a continuation of application No. 15/499,013, filed on Apr. 27, 2017, granted, now 10,106,527, issued on Oct. 23, 2018.
Claims priority of provisional application 62/328,255, filed on Apr. 27, 2016.
Prior Publication US 2023/0286945 A1, Sep. 14, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/496 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 413/14 (2006.01); C07D 417/04 (2006.01); C07D 417/14 (2006.01); C07D 471/08 (2006.01); C07D 471/10 (2006.01); C07D 487/04 (2006.01); C07D 487/08 (2006.01); C07D 491/048 (2006.01)
CPC C07D 401/14 (2013.01) [C07D 401/04 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/04 (2013.01); C07D 417/14 (2013.01); C07D 471/08 (2013.01); C07D 471/10 (2013.01); C07D 487/04 (2013.01); C07D 487/08 (2013.01); C07D 491/048 (2013.01)] 21 Claims
 
1. A pharmaceutical composition comprising a compound which is

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.