	US 12,281,094 B2
	Preparation method of racemic nicotine
Jun Zou, Guangdong (CN); Yang Zou, Guangdong (CN); Meisen Liu, Guangdong (CN); and Weixian Luo, Guangdong (CN)
Assigned to SHENZHEN ZINWI BIO-TECH CO., LTD, Guangdong (CN)
Filed by SHENZHEN ZINWI BIO-TECH CO., LTD, Guangdong (CN)
Filed on Dec. 10, 2021, as Appl. No. 17/547,254.
Application 17/547,254 is a continuation of application No. PCT/CN2021/115397, filed on Aug. 30, 2021.
Claims priority of application No. 202110858727.3 (CN), filed on Jul. 28, 2021.
Prior Publication US 2023/0075688 A1, Mar. 9, 2023
Int. Cl. C07D 401/04 (2006.01)

CPC C07D 401/04 (2013.01)

10 Claims

1. A preparation method of a racemic nicotine, comprising the following steps:

step S1, reacting nicotinyl chloride with methylamine at the presence of an alkali to obtain methylnicotinamide;

step S2, condensing methylnicotinamide with chloroacetone at the presence of an organic base to obtain N-methyl-N-(2-oxpropyl)nicotinamide;

step S3, self-aldol condensing N-methyl-N-(2-oxpropyl)nicotinamide to obtain 1-methyl-5-(pyridin-3-yl)-1,2-dihydro-3H-pyrrol-3-one; and

step S4, reacting 1-methyl-5-(pyridin-3-yl)-1,2-dihydro-3H-pyrrol-3-one with a reducing agent to obtain the racemic nicotine.