US 12,281,073 B2
Substituted piperidine compound and use thereof
Tatsuhiko Fujimoto, Fujisawa (JP); Kentaro Rikimaru, Fujisawa (JP); Koichiro Fukuda, Fujisawa (JP); Hiromichi Sugimoto, Tokyo (JP); Takahiro Matsumoto, Fujisawa (JP); Norihito Tokunaga, Fujisawa (JP); and Mariko Hirozane, Fujisawa (JP)
Assigned to Takeda Pharmaceutical Company Limited, Osaka (JP)
Filed by Takeda Pharmaceutical Company Limited, Osaka (JP)
Filed on Jul. 5, 2023, as Appl. No. 18/347,345.
Application 16/410,463 is a division of application No. 15/421,702, filed on Feb. 1, 2017, granted, now 10,287,305, issued on May 14, 2019.
Application 18/347,345 is a continuation of application No. 17/154,712, filed on Jan. 21, 2021, abandoned.
Application 17/154,712 is a continuation of application No. 16/410,463, filed on May 13, 2019, granted, now 10,898,737, issued on Jan. 26, 2021.
Claims priority of application No. 2016-019834 (JP), filed on Feb. 4, 2016.
Prior Publication US 2024/0174610 A1, May 30, 2024
Int. Cl. C07D 213/61 (2006.01); A61P 25/00 (2006.01); C07D 211/24 (2006.01); C07D 211/36 (2006.01); C07D 211/56 (2006.01); C07D 213/30 (2006.01); C07D 213/74 (2006.01); C07D 213/75 (2006.01); C07D 215/44 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/06 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 409/06 (2006.01); C07D 409/12 (2006.01); C07D 413/06 (2006.01); C07D 417/06 (2006.01); C07D 417/14 (2006.01)
CPC C07D 211/24 (2013.01) [A61P 25/00 (2018.01); C07D 211/36 (2013.01); C07D 211/56 (2013.01); C07D 213/30 (2013.01); C07D 213/61 (2013.01); C07D 213/74 (2013.01); C07D 213/75 (2013.01); C07D 215/44 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/06 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/06 (2013.01); C07D 409/12 (2013.01); C07D 413/06 (2013.01); C07D 417/06 (2013.01); C07D 417/14 (2013.01)] 20 Claims
 
1. A compound having formula (III)

OG Complex Work Unit Chemistry
wherein R2 is a cyclohexyl group substituted with a substituted phenyl group;
wherein the phenyl group is substituted with a hydroxy group, an optionally substituted C1-6 alkoxy group, or a C7-16 aralkyloxy group.