US 12,280,371 B2
Detection chip and detection system
Haochen Cui, Beijing (CN); Jing Li, Beijing (CN); Tao Hu, Beijing (CN); Lijiao Hu, Beijing (CN); Chungen Yuan, Beijing (CN); and Xiaohe Shen, Beijing (CN)
Assigned to BEIJING BOE HEALTH TECHNOLOGY CO., LTD., Beijing (CN); and BOE TECHNOLOGY GROUP CO., LTD., Beijing (CN)
Appl. No. 17/609,816
Filed by BEIJING BOE HEALTH TECHNOLOGY CO., LTD., Beijing (CN); and BOE TECHNOLOGY GROUP CO., LTD., Beijing (CN)
PCT Filed Jan. 15, 2021, PCT No. PCT/CN2021/071966
§ 371(c)(1), (2) Date Nov. 9, 2021,
PCT Pub. No. WO2021/159914, PCT Pub. Date Aug. 19, 2021.
Claims priority of application No. 202010086487.5 (CN), filed on Feb. 11, 2020.
Prior Publication US 2022/0226818 A1, Jul. 21, 2022
Int. Cl. B01L 3/00 (2006.01)
CPC B01L 3/502715 (2013.01) [B01L 2200/0689 (2013.01); B01L 2200/12 (2013.01); B01L 2200/16 (2013.01); B01L 2300/0645 (2013.01); B01L 2300/0819 (2013.01); B01L 2300/0867 (2013.01); B01L 2300/087 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A detection chip, comprising: a base substrate, a flow channel defining layer, and at least one driving electrode group,
wherein the at least one driving electrode group is on the base substrate, and the flow channel defining layer is on a side of the at least one driving electrode group away from the base substrate;
the flow channel defining layer comprises a flow channel structure, and the flow channel structure is configured to accommodate liquid; and
each of the at least one driving electrode group comprises a plurality of driving electrodes, and the plurality of driving electrodes are configured to contact the liquid and drive the liquid to move within the flow channel structure,
the detection chip further comprises: a mixing region, a buffer region, and a detection region, which are arranged in sequence, wherein the flow channel defining layer is at least in the mixing region, the buffer region, and the detection region, the at least one driving electrode group is configured to drive the liquid to sequentially pass through the mixing region, the buffer region, and the detection region,
the flow channel structure comprises a first flow channel portion, a second flow channel portion, and a third flow channel portion which are sequentially connected; the first flow channel portion is in the mixing region and is configured to allow the liquid to be mixed with a reaction reagent in the first flow channel portion; the second flow channel portion is in the buffer region; and the third flow channel portion is in the detection region and is configured to allow to perform optical detection on the liquid at least one detection point in the third flow channel portion,
wherein a cross-sectional shape of the first flow channel portion on a plane parallel to the base substrate is a rhombus, and
a largest dimension of the first flow channel portion in a first direction is greater than a largest dimension of the second flow channel portion in the first direction and greater than a largest dimension of the third flow channel portion in the first direction, the first direction is perpendicular to an extending direction of the flow channel structure.
 
15. A detection system, comprising a detection chip, a control device, and a chip mounting structure,
wherein the detection chip comprises a base substrate, a flow channel defining layer, and at least one driving electrode group, the at least one driving electrode group is on the base substrate, the flow channel defining layer is on a side of the at least one driving electrode group away from the base substrate, the flow channel defining layer comprises a flow channel structure, the flow channel structure is configured to accommodate liquid, each of the at least one driving electrode group comprises a plurality of driving electrodes, and the plurality of driving electrodes are configured to contact the liquid and drive the liquid to move within the flow channel structure, the detection chip further comprises: a mixing region, a buffer region, and a detection region, which are arranged in sequence, wherein the flow channel defining layer is at least in the mixing region, the buffer region, and the detection region, the at least one driving electrode group is configured to drive the liquid to sequentially pass through the mixing region, the buffer region, and the detection region, the flow channel structure comprises a first flow channel portion, a second flow channel portion, and a third flow channel portion which are sequentially connected; the first flow channel portion is in the mixing region and is configured to allow the liquid to be mixed with a reaction reagent in the first flow channel portion; the second flow channel portion is in the buffer region; and the third flow channel portion is in the detection region and is configured to allow to perform optical detection on the liquid at least one detection point in the third flow channel portion, wherein a cross-sectional shape of the first flow channel portion on a plane parallel to the base substrate is a rhombus, and a largest dimension of the first flow channel portion in a first direction is greater than a largest dimension of the second flow channel portion in the first direction and greater than a largest dimension of the third flow channel portion in the first direction, the first direction is perpendicular to an extending direction of the flow channel structure;
the chip mounting structure comprises a signal application electrode, the chip mounting structure is configured to mount the detection chip, and in a case where the detection chip is mounted on the chip mounting structure, the signal application electrode is electrically connected to the plurality of driving electrodes in the each of the at least one driving electrode group; and
the control device is configured to apply an electrical signal to the plurality of driving electrodes in the each of the at least one driving electrode group through the signal application electrode, so as to drive the liquid to move and adjust a movement rate of the liquid.