US 12,280,241 B2
Glucose control system with automatic adaptation of glucose target
Firas H. El-Khatib, Allston, MA (US); Edward R. Damiano, Acton, MA (US); and Steven J. Russell, Lincoln, MA (US)
Assigned to Trustees of Boston University, Boston, MA (US); and The General Hospital Corporation, Boston, MA (US)
Filed by Trustees of Boston University, Boston, MA (US); and The General Hospital Corporation, Boston, MA (US)
Filed on Jul. 18, 2023, as Appl. No. 18/223,315.
Application 18/223,315 is a continuation of application No. 17/099,126, filed on Nov. 16, 2020, granted, now 11,744,945.
Application 17/099,126 is a continuation of application No. 15/748,333, granted, now 10,842,934, issued on Nov. 24, 2020, previously published as PCT/US2016/046008, filed on Aug. 8, 2016.
Claims priority of provisional application 62/202,505, filed on Aug. 7, 2015.
Prior Publication US 2024/0165327 A1, May 23, 2024
Int. Cl. A61M 5/172 (2006.01); A61B 5/00 (2006.01); A61B 5/145 (2006.01); A61M 5/142 (2006.01)
CPC A61M 5/1723 (2013.01) [A61B 5/14532 (2013.01); A61B 5/4839 (2013.01); A61M 2005/14208 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A method of operating a glucose control system having an input/output interface configured to receive a measured glucose level signal indicative of a measured glucose level of a subject from a glucose sensor and to transmit a dose control signal to a delivery device configured to deliver doses of at least one glucose control agent for infusion into the subject, the method comprising:
by an electronic processor of the glucose control system configured to execute a control scheme to generate the dose control signal in response to (a) the measured glucose level signal and (b) a target glucose level signal, wherein the electronic processor is configured to execute specific computer-executable instructions stored in a non-transitory memory connected to the electronic processor:
calculating corrective doses of the at least one glucose control agent based on a target glucose level signal and variations of the glucose level signal occurring over a correction dose period on the order of seconds to minutes;
calculating an adapted value of the target glucose level signal based at least on a function of the glucose level signal over at least a portion of a target glucose level calculation period that is longer than the correction dose period, wherein the function is a weighted sum using a scaling factor with which measured glucose levels are multiplied to determine offsets caused on the adapted value of the target glucose level signal by respective contributions from measured glucose levels of the subject, and wherein the scaling factor varies depending on the respective measured glucose levels of the subject; and
generating the dose control signal to cause delivery of corrective doses calculated using the adapted value of the target glucose level signal,
wherein the glucose control agent comprises at least one of insulin or an insulin analog.