US 12,280,222 B2
Systems and methods for injection and aspiration
Bradley S. Culbert, Mission Viejo, CA (US); and Gary D Carlson, Aliso Viejo, CA (US)
Assigned to Incuvate, LLC, Irvine, CA (US)
Filed by INCUVATE, LLC, Irvine, CA (US)
Filed on Jun. 26, 2024, as Appl. No. 18/755,567.
Claims priority of provisional application 63/579,255, filed on Aug. 28, 2023.
Prior Publication US 2025/0073425 A1, Mar. 6, 2025
Int. Cl. A61M 25/00 (2006.01); A61M 1/00 (2006.01)
CPC A61M 25/0082 (2013.01) [A61M 1/80 (2021.05); A61M 1/87 (2021.05); A61M 2205/33 (2013.01); A61M 2205/3331 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A system for catheter-based aspiration, comprising:
an aspiration catheter having a distal portion configured for insertion within a blood vessel of a subject, the aspiration catheter comprising:
an aspiration lumen having a distal opening at the distal portion of the aspiration catheter;
an injection lumen having a distal end at the distal portion of the aspiration catheter; and
an orifice located at or near the distal end of the injection lumen, the orifice configured to direct liquid into the aspiration lumen at or near the distal opening of the aspiration lumen;
an injector configured to pressurize the liquid within the injection lumen, such that liquid exits the orifice and enters the aspiration lumen; and
a mechanical oscillator coupled to the injector and configured to cause a pulsatile pressure of the liquid as it is injected through the injection lumen, wherein the injector comprises a barrel and a plunger, the plunger sealingly displaceable within an interior of the barrel along a longitudinal displacement axis, wherein the mechanical oscillator comprises a first disk and a second disk axially arrayed with respect to each other and configured such that changes based upon relative rotational orientation between the first disk and the second disk cause reciprocal relative axial displacement between the first disk and the second disk, and wherein the first disk is coupled to the plunger and configured to transfer motive force thereto along the longitudinal displacement axis.