US 12,280,196 B2
Methods of using polymers
Phillip P. Chan, Cherry Hill, NJ (US); Vincent J. Capponi, Lawrenceville, NJ (US); Thomas D. Golobish, Princeton, NJ (US); and Humayra Begum Ali, Princeton, NJ (US)
Assigned to CytoSorbents, Inc., Princeton, NJ (US)
Filed by CytoSorbents, Inc., Princeton, NJ (US)
Filed on Aug. 30, 2022, as Appl. No. 17/823,120.
Application 17/823,120 is a continuation of application No. 15/497,640, filed on Apr. 26, 2017, granted, now 11,602,585.
Application 15/497,640 is a continuation of application No. 14/410,901, abandoned, previously published as PCT/US2013/048615, filed on Jun. 28, 2013.
Claims priority of provisional application 61/666,626, filed on Jun. 29, 2012.
Prior Publication US 2023/0166019 A1, Jun. 1, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61M 1/36 (2006.01); A61K 9/16 (2006.01); A61K 31/765 (2006.01); B01J 20/26 (2006.01); B01J 20/28 (2006.01); C08F 299/00 (2006.01); C08J 9/26 (2006.01)
CPC A61M 1/3679 (2013.01) [A61K 9/16 (2013.01); A61K 31/765 (2013.01); B01J 20/261 (2013.01); B01J 20/28069 (2013.01); B01J 20/28078 (2013.01); C08F 299/00 (2013.01); C08J 9/26 (2013.01); A61M 2202/0057 (2013.01); A61M 2202/0405 (2013.01); A61M 2202/0413 (2013.01); A61M 2202/0415 (2013.01); A61M 2202/0423 (2013.01); A61M 2202/0464 (2013.01); A61M 2202/0466 (2013.01); A61M 2202/049 (2013.01); A61M 2202/0492 (2013.01); A61M 2202/0496 (2013.01); A61M 2202/20 (2013.01); A61M 2202/203 (2013.01); A61M 2202/206 (2013.01); C08J 2201/0444 (2013.01); C08J 2207/10 (2013.01); C08J 2353/00 (2013.01)] 24 Claims
 
1. A method of reducing contamination by at least two toxins in a biological substance, said method comprising:
a. contacting the biological substance with an effective amount of a sorbent capable of sorbing the toxins, wherein the sorbent comprises a plurality of pores ranging from 50 Å to 40,000 Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm, wherein the sorbent comprises a coated polymer comprising at least one crosslinking agent and wherein said toxins comprise a first toxin having a molecular weight of less than or equal to 50,000 Daltons and a second toxin having a molecular weight greater than 50,000 Daltons; and
b. sorbing the toxins.