US 12,280,177 B2
Functionalization of plant tissues for human cell expansion
William L. Murphy, Waunakee, WI (US); Gianluca Fontana, Matera, WI (US); Joshua Gershlak, Melrose, MA (US); Glenn Gaudette, Holden, MA (US); Pam Weathers, Stow, MA (US); Tanja Dominko, Verona, MA (US); Marsha Rolle, Worchester, MA (US); Sarah Hernandez, Carver, MA (US); Carol Cramer, Jonesboro, AR (US); Luis Fabircio Medina-Bolivar, Memphis, TN (US); and Bernard Binder, Pleasant Hill, CA (US)
Assigned to Wisconsin Alumni Research Foundation, Madison, WI (US); ARKANSAS STATE UNIVERSITY—JONESBORO, State University, AR (US); and Worcester Polytechnic Institute, Worcester, MA (US)
Filed by Wisconsin Alumni Research Foundation, Madison, WI (US); ARKANSAS STATE UNIVERSITY—JONESBORO, State University, AR (US); and Worcester Polytechnic Institute, Worcester, MA (US)
Filed on Jul. 29, 2021, as Appl. No. 17/388,652.
Application 17/388,652 is a continuation of application No. 16/085,220, abandoned, previously published as PCT/US2017/022336, filed on Mar. 14, 2017.
Claims priority of provisional application 62/462,653, filed on Feb. 23, 2017.
Claims priority of provisional application 62/318,953, filed on Apr. 6, 2016.
Claims priority of provisional application 62/307,771, filed on Mar. 14, 2016.
Prior Publication US 2022/0054708 A1, Feb. 24, 2022
Int. Cl. A61L 27/36 (2006.01); A61L 27/12 (2006.01); A61L 27/22 (2006.01); A61L 27/38 (2006.01); A61L 27/54 (2006.01); C12N 5/00 (2006.01); C12N 5/04 (2006.01)
CPC A61L 27/3637 (2013.01) [A61L 27/12 (2013.01); A61L 27/227 (2013.01); A61L 27/3834 (2013.01); A61L 27/54 (2013.01); C12N 5/0068 (2013.01); C12N 5/04 (2013.01); A61L 2300/25 (2013.01); A61L 2300/412 (2013.01); A61L 2300/414 (2013.01); C12N 2533/90 (2013.01); C12N 2535/00 (2013.01)] 15 Claims
 
1. A plant scaffold comprising a decellularized plant tissue comprising a plant adhesion molecule conjugated to a cell adhesion peptide, wherein the plant scaffold has a perfusable structure.