US 12,280,156 B2
Compositions and methods for targeted delivery of therapeutic and/or diagnostic species
Daniel J. Hayes, State College, PA (US); and Mohammad Abu-Laban, State College, PA (US)
Assigned to THE PENN STATE RESEARCH FOUNDATION, University Park, PA (US)
Filed by THE PENN STATE RESEARCH FOUNDATION, University Park, PA (US)
Filed on Dec. 7, 2022, as Appl. No. 18/076,772.
Application 18/076,772 is a continuation of application No. 16/630,806, granted, now 11,559,494, previously published as PCT/US2018/042017, filed on Jul. 13, 2018.
Claims priority of provisional application 62/532,536, filed on Jul. 14, 2017.
Prior Publication US 2023/0109863 A1, Apr. 13, 2023
Int. Cl. A61K 9/50 (2006.01); A61K 9/51 (2006.01)
CPC A61K 9/5094 (2013.01) [A61K 9/5115 (2013.01)] 20 Claims
 
1. A composition suitable for in vivo administration to a subject comprising:
a metal nanoparticle;
a therapeutic species; and
a linker joining the metal nanoparticle to the therapeutic species,
wherein the linker comprises a Diels-Alder cyclo-addition reaction product,
wherein the Diels-Alder cyclo-addition reaction product has a retro Diels-Alder reaction activation temperature between 30° C. and 180° C.,
wherein the metal nanoparticle has a plasmon resonance frequency in a visible region, in a near infrared region, or in an infrared region of the electromagnetic spectrum, such that upon administration of the composition to a biological compartment of the subject and applying to the biological compartment a wavelength of light matching the plasmon resonance frequency of the metal nanoparticle, the retro Diels-Alder reaction activation temperature is achieved resulting in a retro Diels-Alder reaction that cleaves the linker and releases the therapeutic species in the biological compartment of the subject.