US 12,280,145 B1
Method of preparing nanoparticles by hot-melt extrusion
Eric Daniel Morrison, West St. Paul, MN (US)
Filed by Eric Daniel Morrison, West St. Paul, MN (US)
Filed on Oct. 14, 2022, as Appl. No. 18/046,778.
Application 18/046,778 is a continuation of application No. 16/748,399, filed on Jan. 21, 2020, granted, now 11,504,327.
Claims priority of provisional application 62/843,763, filed on May 6, 2019.
Claims priority of provisional application 62/794,742, filed on Jan. 21, 2019.
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/107 (2006.01); A61K 9/00 (2006.01); A61K 31/192 (2006.01); A61K 47/06 (2006.01); A61K 47/08 (2006.01); A61K 47/14 (2017.01); A61K 47/24 (2006.01); A61K 47/26 (2006.01); A61K 47/34 (2017.01); A61K 47/44 (2017.01)
CPC A61K 9/1075 (2013.01) [A61K 9/0014 (2013.01); A61K 31/192 (2013.01); A61K 47/06 (2013.01); A61K 47/08 (2013.01); A61K 47/14 (2013.01); A61K 47/24 (2013.01); A61K 47/26 (2013.01); A61K 47/34 (2013.01); A61K 47/44 (2013.01)] 22 Claims
 
1. A nanoparticle dispersion comprising;
from 0.5 wt. % to 8.5% of one or more hydrophobic drugs and/or hydrophobic bioactive agents;
from 1.6 wt. % to 11.9 wt. % of one or more high hydrophile-lipophile-balance (HLB) surfactants;
from 2.6 wt. % to 12.0 wt. % of one or more low hydrophile-lipophile-balance (HLB) surfactants;
from 13.9 wt. % to 41.8 wt. % of one or more water immiscible oils; and
from 39.1 wt. % to 58.1 wt. % water, wherein:
the dispersion is without lamellar structure; and
the dispersion has a latent lamellar structure.