	US 12,280,133 B1
	Glabridin composition with high skin permeability, and preparation method and use thereof
Haiyan Liu, Guangzhou (CN); Sen Hou, Guangzhou (CN); Anzhang Li, Guangzhou (CN); Tuzhen Yang, Guangzhou (CN); Jie Wei, Guangzhou (CN); and Anning Wang, Guangzhou (CN)
Assigned to Guangzhou Fanzhirong Cosmetics Co., Ltd., Guangzhou (CN); and Guangzhou Qingnang Biotechnology Co., Ltd., Guangzhou (CN)
Filed by Guangzhou Fanzhirong Cosmetics Co., Ltd., Guangzhou (CN); and Guangzhou Qingnang Biotechnology Co., Ltd., Guangzhou (CN)
Filed on Nov. 12, 2024, as Appl. No. 18/945,317.
Claims priority of application No. 202411035288.6 (CN), filed on Jul. 31, 2024.
Int. Cl. A61K 8/49 (2006.01); A61K 8/34 (2006.01); A61K 8/37 (2006.01); A61K 8/44 (2006.01); A61K 8/67 (2006.01); A61K 8/86 (2006.01); A61Q 19/02 (2006.01)

CPC A61K 8/498 (2013.01) [A61K 8/345 (2013.01); A61K 8/375 (2013.01); A61K 8/44 (2013.01); A61K 8/676 (2013.01); A61K 8/86 (2013.01); A61Q 19/02 (2013.01)]

10 Claims

1. A glabridin composition prepared from:

A) an S1 phase consisting of an oil and glabridin;

B) an S2 phase consisting 3-O-ethyl ascorbic acid, an anionic surfactant, a nonionic surfactant, a polyol and water; and

C) water as an S3 phase,

wherein:

the nonionic surfactant is oleth-20 and polyglycerol-10-oleate;

the oil is caprylic acid/capric acid triglyceride;

the polyol is 1,3-butanediol; and

the anionic surfactant is sodium stearoyl glutamate,

and based on a total mass, the glabridin composition comprises:

0.10-4.00 wt % glabridin;

0.10-4.00 wt % 3-O-ethyl ascorbic acid;

0.70-10.00 wt % nonionic surfactant;

1.00-40.00 wt % oil;

0.60-6.00 wt % polyol;

0.10-1.00 wt % anionic surfactant;

0.30-3.00 wt % water in the S2 phase; and

balance is S3 phase.