	US 12,280,125 B2
	Method for delivering insulin
B. Rabindran Jermy, Dammam (SA); Vijaya Ravinayagam, Dammam (SA); and Mohammed Salahuddin, Dammam (SA)
Assigned to Imam Abdulrahman Bin Faisal University, Dammam (SA)
Filed by Imam Abdulrahman Bin Faisal University, Dammam (SA)
Filed on Sep. 9, 2022, as Appl. No. 17/941,384.
Prior Publication US 2024/0082422 A1, Mar. 14, 2024
Int. Cl. A61K 47/69 (2017.01); A61K 9/00 (2006.01); A61K 38/28 (2006.01); A61K 47/60 (2017.01)

CPC A61K 47/6923 (2017.08) [A61K 9/0053 (2013.01); A61K 38/28 (2013.01); A61K 47/60 (2017.08)]

17 Claims

1. A method of delivering insulin, comprising:

orally administering to a subject a composition comprising,

a ferrisilicate material having one or more pores, the one or more pores having an average pore size of from 2 nm to 5 nm;

polyethylene glycol; and

insulin;

wherein the insulin at least partially penetrates the pores of the ferrisilicate material to form a ferrisilicate insulin composite,

wherein the polyethylene glycol, at least partially enfolds the ferrisilicate insulin composite, and

wherein the composition has a cumulative insulin release of about 40% after 500 hours following oral administration.