CPC A61K 39/215 (2013.01) [C07K 14/165 (2013.01); C07K 14/1808 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C12N 2770/20034 (2013.01); C12N 2770/36141 (2013.01)] | 16 Claims |
1. An isolated polynucleotide, which encodes alphavirus non-structural proteins nsP1, nsP2, nsP3, and nsP4 and
a polypeptide comprising a receptor binding domain (RBD) of an S1 subunit in a spike protein of a SARS-CoV2 fused to a transmembrane domain and optionally to a signal sequence,
wherein the alphavirus is Venezuelan Equine Encephalitis Virus or Chikungunya virus, and
wherein the transmembrane domain is heterologous to the SARS-CoV-2.
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