US 12,280,087 B2
Composition comprising self-assembling peptides for use in treatment of gingivitis, periodontitis and/or peri-implantitis
Michael Hug, Zofingen (CH); Dominikus Amadeus Lysek, Windisch (CH); Franziska Koch, Kandern-Tannenkirch (DE); Ronald Jung, Küsnacht (CH); Stephanie Mathes, Neftenbach (CH); Nina Meyer, Zürich (CH); Christoph Hämmerle, Benglen (CH); Frank Bröseler, Aachen (DE); and Uwe Pieles, Müllheim/Baden (DE)
Assigned to Credentis AG, Windisch (CH)
Appl. No. 16/319,943
Filed by Credentis AG, Windisch (CH)
PCT Filed Aug. 16, 2017, PCT No. PCT/EP2017/070758
§ 371(c)(1), (2) Date Jan. 23, 2019,
PCT Pub. No. WO2018/033570, PCT Pub. Date Feb. 22, 2018.
Claims priority of application No. 16184309 (EP), filed on Aug. 16, 2016; and application No. 16200655 (EP), filed on Nov. 25, 2016.
Prior Publication US 2019/0247540 A1, Aug. 15, 2019
Int. Cl. A61K 38/08 (2019.01); A61K 8/64 (2006.01); A61K 9/00 (2006.01); A61K 45/06 (2006.01); A61L 27/22 (2006.01); A61L 27/52 (2006.01); A61L 27/54 (2006.01); A61L 31/04 (2006.01); A61L 31/14 (2006.01); A61L 31/16 (2006.01); A61Q 11/00 (2006.01); A61P 1/02 (2006.01); A61P 31/04 (2006.01)
CPC A61K 38/08 (2013.01) [A61K 8/64 (2013.01); A61K 9/006 (2013.01); A61K 9/0063 (2013.01); A61K 45/06 (2013.01); A61L 27/227 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); A61L 31/047 (2013.01); A61L 31/145 (2013.01); A61L 31/16 (2013.01); A61Q 11/00 (2013.01); A61L 2300/406 (2013.01); A61L 2300/41 (2013.01); A61L 2430/12 (2013.01); A61P 1/02 (2018.01); A61P 31/04 (2018.01)] 19 Claims
 
1. A method for treating an oral disease in a subject, comprising
inserting a composition comprising self-assembling peptides into a pocket caused by gum and/or bone recession,
wherein the self-assembling peptides are 11 amino acids in length, comprise the amino acid sequence SEQ ID NO:1, and have at least 81% sequence identity to SEQ ID NO: 6,
wherein the self-assembling peptides are capable of self-assembly at a pH below 7.5 and at least physiologic ionic strength, and
wherein the oral disease is selected from the group consisting of periodontitis, peri-implantitis and/or gingivitis.