US 12,280,072 B2
Oligosaccharide compound for inhibiting intrinsic coagulation factor X-enzyme complex, and preparation method therefor and uses thereof
Jinhua Zhao, Kunming (CN); Zhenguo Li, Changsha (CN); Na Gao, Kunming (CN); Mingyi Wu, Kunming (CN); Yanming Chen, Mudanjiang (CN); Longyan Zhao, Kunming (CN); Yongsheng Wu, Mudanjiang (CN); Zi Li, Kunming (CN); Chuang Xiao, Kunming (CN); Shunliang Zheng, Mudanjiang (CN); Zhiyuan Nan, Mudanjiang City (CN); Jianbo Zhou, Mudanjiang (CN); Jianping Xu, Kunming (CN); Lutan Zhou, Kunming (CN); Yafang Guo, Mudanjiang (CN); Hongbo Qin, Kunming (CN); and Jikai Liu, Kunming (CN)
Assigned to Jiuzhitang Co., Ltd., (CN); and Mudanjiang YouBo Pharmaceutical Co., Ltd, (CN)
Filed by Jiuzhitang Co., Ltd., Changsha (CN); and Mudanjiang YouBo Pharmaceutical Co., Ltd., Heilongjiang (CN)
Filed on Sep. 28, 2023, as Appl. No. 18/374,543.
Application 18/374,543 is a division of application No. 16/476,720, previously published as PCT/CN2017/070716, filed on Jan. 10, 2017.
Prior Publication US 2024/0041918 A1, Feb. 8, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/727 (2006.01); A61K 9/00 (2006.01); A61P 7/02 (2006.01)
CPC A61K 31/727 (2013.01) [A61K 9/0019 (2013.01); A61P 7/02 (2018.01)] 7 Claims
 
1. An oligosaccharide compound or a pharmaceutically acceptable salt thereof, characterized in that, the oligosaccharide compound has antithrombotic activity, and has a general structure represented by Formula (I):

OG Complex Work Unit Chemistry
in the formula,
n is a number from 0 to 8;
R1, R2, R3, R4, and R5 are independently H or —SO3H; or
R6 is independently —H, a substituted or unsubstituted C1-C6 hydrocarbon group or a C7-C12 aryl group;
R7 is —H, —SO3H, C2-C5 acyl;
R8 is Formula (III):

OG Complex Work Unit Chemistry
in Formula (III),
R1, R2, R3, R4, R5, R6 and R7 are defined as above; and
R10 is independently —H, a substituted or unsubstituted C1-C6 hydrocarbon group or a C7-C12 aryl group.