US 12,280,044 B2
Proteolysis-targeting chimera molecule and preparation method and use thereof
Du Feng, Guangdong (CN); Wei Yi, Guangdong (CN); Yongquan Hu, Guangdong (CN); Junyuan Tang, Guangdong (CN); Zhi Zhou, Guangdong (CN); and Haixia Zhuang, Guangdong (CN)
Assigned to GUANGZHOU MEDICAL UNIVERSITY, Guangzhou (CN)
Filed by GUANGZHOU MEDICAL UNIVERSITY, Guangdong (CN)
Filed on Jan. 29, 2024, as Appl. No. 18/426,321.
Application 18/426,321 is a continuation of application No. PCT/CN2023/092388, filed on May 5, 2023.
Claims priority of application No. 202210830254.0 (CN), filed on Jul. 14, 2022.
Prior Publication US 2024/0245671 A1, Jul. 25, 2024
Int. Cl. A61K 31/4545 (2006.01); A61K 8/49 (2006.01); A61Q 19/02 (2006.01)
CPC A61K 31/4545 (2013.01) [A61K 8/4933 (2013.01); A61Q 19/02 (2013.01)] 1 Claim
 
1. A proteolysis-targeting chimera (PROTAC) molecule, wherein a structural formula of the PROTAC molecule is any one selected from the group consisting of formulas (II) to (IV):

OG Complex Work Unit Chemistry
wherein R1 is H or OH, n is 2 to 8, and Y is CH2 or CO;

OG Complex Work Unit Chemistry
wherein R1 is H or OH, n is 2 to 8, X is O, and Y is CH2 or CO; and

OG Complex Work Unit Chemistry
wherein R1 is H or OH, n is 2 to 8, and Y is CH2 or CO.