	US 12,280,032 B2
	Methods and compositions for increasing the potency of antifungal agents
Catherine Ludlow, Seattle, WA (US); Aimee M. Dudley, Seattle, WA (US); and Zhihao Tan, Seattle, WA (US)
Assigned to PACIFIC NORTHWEST RESEARCH INSTITUTE, Seattle, WA (US)
Filed by Pacific Northwest Research Institute, Seattle, WA (US)
Filed on Aug. 10, 2022, as Appl. No. 17/885,464.
Application 16/927,816 is a division of application No. 15/516,879, granted, now 10,751,317, issued on Aug. 25, 2020, previously published as PCT/US2015/054304, filed on Oct. 6, 2015.
Application 17/885,464 is a continuation of application No. 16/927,816, filed on Jul. 13, 2020, granted, now 11,446,271.
Claims priority of provisional application 62/190,660, filed on Jul. 9, 2015.
Claims priority of provisional application 62/061,579, filed on Oct. 8, 2014.
Prior Publication US 2023/0060217 A1, Mar. 2, 2023
Int. Cl. A61K 31/277 (2006.01); A01N 31/04 (2006.01); A61K 31/045 (2006.01); A61K 31/05 (2006.01); A61K 31/136 (2006.01); A61K 31/137 (2006.01); A61K 31/138 (2006.01); A61K 31/365 (2006.01); A61K 31/4164 (2006.01); A61K 31/4196 (2006.01); A61K 31/496 (2006.01); A61K 31/505 (2006.01); A61K 31/506 (2006.01); A61K 31/513 (2006.01); A61K 31/5375 (2006.01); A61K 31/704 (2006.01); A61K 31/7048 (2006.01); A61K 45/06 (2006.01); A61L 15/44 (2006.01); A61L 27/34 (2006.01); A61L 27/54 (2006.01); A61L 29/08 (2006.01); A61L 29/16 (2006.01); A61L 31/10 (2006.01); A61L 31/16 (2006.01); C12Q 1/18 (2006.01); G01R 1/04 (2006.01); G01R 1/067 (2006.01); G01R 1/073 (2006.01); A61F 6/04 (2006.01)

CPC A61K 31/277 (2013.01) [A01N 31/04 (2013.01); A61K 31/045 (2013.01); A61K 31/05 (2013.01); A61K 31/136 (2013.01); A61K 31/137 (2013.01); A61K 31/138 (2013.01); A61K 31/365 (2013.01); A61K 31/4164 (2013.01); A61K 31/4196 (2013.01); A61K 31/496 (2013.01); A61K 31/505 (2013.01); A61K 31/506 (2013.01); A61K 31/513 (2013.01); A61K 31/5375 (2013.01); A61K 31/704 (2013.01); A61K 31/7048 (2013.01); A61K 45/06 (2013.01); A61L 15/44 (2013.01); A61L 27/34 (2013.01); A61L 27/54 (2013.01); A61L 29/085 (2013.01); A61L 29/16 (2013.01); A61L 31/10 (2013.01); A61L 31/16 (2013.01); C12Q 1/18 (2013.01); G01R 1/0433 (2013.01); G01R 1/06722 (2013.01); G01R 1/073 (2013.01); A61F 6/04 (2013.01); A61L 2300/404 (2013.01); G01N 2333/37 (2013.01); G01N 2333/40 (2013.01)]

17 Claims

1. A method of increasing a sensitivity of a fungal pathogen to an antifungal agent, the method comprising:

coating a surface of a medical device with a phenyl ethanol as a sensitizing agent in combination with the antifungal agent in amounts to yield a synergistically antifungal effect on the surface,

wherein the phenyl ethanol is a phenyl ethanol structural derivative in Table 3 or is a structure of Formula I, wherein the structure of Formula I is:

wherein X is selected from the group consisting of C, N, S and O;

R₁, R₂, R₃, R₄, and R₅are each independently selected from hydrogen, C₁to C₆alkyl, substituted C₁to C₆alkyl, C₂to C₆alkenyl, substituted C₂to C₆alkenyl; aryl, heteroaryl, alkoxy, or aryloxy; and

n is 1, 2, 3, 4, 5 or 6.