US 12,280,031 B2
Teriflunomide topical pharmaceutical compositions
Venkata Nookaraju Sreedharala, Hyderabad (IN); Ramdas Manakkote, Hyderabad (IN); and Srikanth Kalakoti, Hyderabad (IN)
Assigned to APRAMITHA INNOVATIONS PRIVATE LIMITED, Telangana (IN)
Appl. No. 17/291,006
Filed by APRAMITHA INNOVATIONS PRIVATE LIMITED, Telangana (IN)
PCT Filed Nov. 5, 2019, PCT No. PCT/IN2019/050818
§ 371(c)(1), (2) Date May 4, 2021,
PCT Pub. No. WO2020/095319, PCT Pub. Date May 14, 2020.
Claims priority of application No. 201841041818 (IN), filed on Nov. 5, 2018.
Prior Publication US 2022/0040138 A1, Feb. 10, 2022
Int. Cl. A61K 31/277 (2006.01); A61K 9/06 (2006.01); A61K 45/06 (2006.01)
CPC A61K 31/277 (2013.01) [A61K 9/06 (2013.01); A61K 45/06 (2013.01)] 19 Claims
 
1. A topical pharmaceutical composition of
(i) teriflunomide or its pharmaceutically acceptable salt in an amount of 0.5% to 10% by weight of the composition;
(ii) a carrier comprising waterer;
(iii) a permeation enhancer; and
(iv) at least one pharmaceutically acceptable excipient;
wherein the teriflunomide or its pharmaceutically acceptable salt to the permeation enhancer is in a weight ratio of 1:1 to 1:20.