US 12,280,017 B2
Methods of treating skin with aromatic skin-active ingredients
Bob Walke, Addison, TX (US); Christi Gomez, Addison, TX (US); Tiffany Carle, Addison, TX (US); and Michelle Hines, Addison, TX (US)
Assigned to MARY KAY INC., Addison, TX (US)
Filed by Mary Kay Inc., Addison, TX (US)
Filed on Jun. 25, 2019, as Appl. No. 16/451,999.
Application 16/451,999 is a continuation of application No. 12/105,957, filed on Apr. 18, 2008, abandoned.
Claims priority of provisional application 61/025,631, filed on Feb. 1, 2008.
Prior Publication US 2019/0314295 A1, Oct. 17, 2019
Int. Cl. A61K 8/37 (2006.01); A61K 8/33 (2006.01); A61K 8/34 (2006.01); A61K 8/35 (2006.01); A61K 8/49 (2006.01); A61K 31/045 (2006.01); A61K 31/335 (2006.01); A61K 31/35 (2006.01); A61K 31/365 (2006.01); A61Q 19/00 (2006.01)
CPC A61K 31/045 (2013.01) [A61K 8/33 (2013.01); A61K 8/34 (2013.01); A61K 8/342 (2013.01); A61K 8/35 (2013.01); A61K 8/37 (2013.01); A61K 8/4973 (2013.01); A61K 8/498 (2013.01); A61K 31/335 (2013.01); A61K 31/35 (2013.01); A61K 31/365 (2013.01); A61Q 19/00 (2013.01); A61K 2800/522 (2013.01)] 3 Claims
 
1. A method of reducing the appearance of a fine line or wrinkle on skin, the method comprising topically applying to the fine line or wrinkle a composition comprising: at least 1% by weight of a combination of 1,4-dioxacycloheptadecane-5,17-dione and methyl 3-oxo-2-pentylcyclopentanecarboxylate to reduce matrix metalloprotease (MMP)-9 activity in the skin, wherein topical application of the composition reduces MMP-9 activity in the skin and reduces the appearance of the fine line or wrinkle on the skin, wherein the 1,4-dioxacycloheptadecane-5,17-dione also reduces skin inflammation by reducing cyclooxygenase (COX)-2 activity in the skin, wherein the composition further comprises 5-heptyldihydrofuran-2(3H)-one in an amount effective to reduce skin inflammation by reducing lipoxygenase (LO) activity in the skin, wherein the skin is also inflamed.