| CPC A61B 5/24 (2021.01) [A61N 1/0472 (2013.01); A61N 1/36128 (2013.01); G16H 40/63 (2018.01)] | 19 Claims |

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1. An electrical stimulation system for delivering spatially random electrical stimulation to a patient through an electrode array during electrical stimulation therapy of the patient, the electrical stimulation system comprising:
an electrode array comprising a plurality of electrodes spaced apart from one another;
a signal generator electrically coupled to the electrode array and configured to deliver an electrical stimulation signal; and
a controller comprising a processor and a memory having a plurality of instructions stored thereon that, in response to execution by the processor, causes the controller to:
randomly select, at periodic intervals based on a predefined period of time, an electrical configuration from the plurality of electrodes of the electrode array during the electrical stimulation therapy, wherein to randomly select the electrical configuration comprises to randomly select a first set of electrodes of the plurality of electrodes to function as electrical sources and a second set of electrodes of the plurality of electrodes, different from the first set of electrodes, to function as electrical sinks; and
instruct the signal generator to deliver the electrical stimulation signal to the patient for the predefined period of time via the randomly selected electrical configuration to improve a condition of the patient;
wherein the plurality of electrodes comprises a third set of electrodes of a first size and a fourth set of electrodes of a second size greater than the first size;
wherein the plurality of instructions further causes the controller to select each of the third set of electrodes and the fourth set of electrodes based on an electrode size;
wherein the signal generator is configured to deliver high-frequency signal components of the electrical stimulation signal through only the third set of electrodes; and
wherein the signal generator is configured to deliver low-frequency signal components of the electrical stimulation signal through only the fourth set of electrodes.
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