US 12,279,630 B2
Treatment and prevention of seed allergies
Mona Kidon, Rishon-LeZion (IL); and Ran Hovav, Mazkeret Batya (IL)
Assigned to Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramat Gan (IL); and The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center), Rishon-LeZion (IL)
Appl. No. 16/961,942
Filed by Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramat-Gan (IL); and The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center), Rishon-LeZion (IL)
PCT Filed Jan. 16, 2019, PCT No. PCT/IL2019/050067
§ 371(c)(1), (2) Date Jul. 14, 2020,
PCT Pub. No. WO2019/142189, PCT Pub. Date Jul. 25, 2019.
Claims priority of provisional application 62/617,642, filed on Jan. 16, 2018.
Prior Publication US 2020/0345033 A1, Nov. 5, 2020
Int. Cl. A23J 1/14 (2006.01); A23J 3/14 (2006.01); A23J 3/34 (2006.01); A23L 25/00 (2016.01); A61K 39/35 (2006.01); A61K 49/00 (2006.01)
CPC A23J 1/146 (2013.01) [A23J 3/14 (2013.01); A23J 3/346 (2013.01); A23L 25/30 (2016.08); A61K 39/35 (2013.01); A61K 49/0004 (2013.01)] 8 Claims
 
1. A method of inducing desensitization to peanut seeds in an allergic subject comprising providing a composition to the subject using a treatment regimen that induces desensitization to peanut seeds in said allergic subject, wherein the composition comprises an extract of a plurality of non-mature peanut seeds, wherein allergic proteins of said non-mature peanut seeds are amenable to heat denaturation and are denatured by heating to a temperature between 50-500° C., wherein said non-mature peanut seeds are at a developmental stage whereby the peanut seeds occupy between 40-60% of the pod volume, said composition of matter being devoid of fully mature peanut seeds.