CPC G01N 33/6854 (2013.01) [C07K 16/241 (2013.01); C07K 16/2875 (2013.01); G01N 33/6863 (2013.01); C07K 2317/565 (2013.01); G01N 2333/525 (2013.01)] | 23 Claims |
1. A method for performing an ex vivo diagnostic test for the presence of A Proliferation-Inducing Ligand (APRIL) in a sample, comprising:
a) contacting the sample with an APRIL-binding antibody comprising:
i) a VH domain comprising an amino acid sequence having complementarity determining region (CDR) sequences set forth in SEQ ID NOs: 25-27, and a VL domain comprising an amino acid sequence comprising CDR sequences set forth in SEQ ID NOs: 28-30,
ii) a VH domain comprising an amino acid sequence having complementarity determining region (CDR) sequences set forth in SEQ ID NOs: 5-7 and a VL domain comprising an amino acid sequence comprising CDR sequences set forth in SEQ ID NOs: 8-10,
iii) a VH domain comprising an amino acid sequence having complementarity determining region (CDR) sequences set forth in SEQ ID NOs: 15-17 and a VL domain comprising an amino acid sequence comprising CDR sequences set forth in SEQ ID NOs: 18-20,
iv) a VH domain comprising an amino acid sequence having complementarity determining region (CDR) sequences set forth in SEQ ID NOs: 35-37 and a VL domain comprising an amino acid sequence comprising CDR sequences set forth in SEQ ID NOs: 38-40, or
v) a VH domain comprising an amino acid sequence having complementarity determining region (CDR) sequences set forth in SEQ ID NOs: 45-47 and a VL domain comprising an amino acid sequence comprising CDR sequences set forth in SEQ ID NOs: 48-50; and
b) detecting binding between APRIL in the human sample and the APRIL-binding antibody.
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