US 11,959,905 B2
System and method for single molecule detection
Stuart Lindsay, Phoenix, AZ (US); Peiming Zhang, Gilbert, AZ (US); and Yanan Zhao, Tempe, AZ (US)
Assigned to ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, Scottsdale, AZ (US)
Filed by ARIZONA BOARD OF REGENTS on behalf of ARIZONA STATE UNIVERSITY, Scottsdale, AZ (US)
Filed on Mar. 3, 2023, as Appl. No. 18/178,130.
Application 18/178,130 is a continuation of application No. 16/917,474, filed on Jun. 30, 2020, granted, now 11,630,098.
Application 16/917,474 is a continuation of application No. 16/537,232, filed on Aug. 9, 2019, abandoned.
Application 16/537,232 is a continuation of application No. 15/375,901, filed on Dec. 12, 2016, granted, now 10,379,102, issued on Aug. 13, 2019.
Claims priority of provisional application 62/266,282, filed on Dec. 11, 2015.
Prior Publication US 2023/0243807 A1, Aug. 3, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 27/327 (2006.01); G01N 33/487 (2006.01)
CPC G01N 33/48721 (2013.01) [G01N 27/3276 (2013.01); G01N 27/3278 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A sensing device for sensing target molecule fluctuations, comprising:
a first electrode and a second electrode separated from the first electrode by a gap; and
at least one recognition molecule comprising a first end with a first chemical composition to bind the first electrode or the second electrode, and a second end with a second chemical composition to bind the target molecule;
wherein the gap is bridged by the target molecule bound by the at least one recognition molecule, thereby completing an electrical circuit.