CPC C12N 15/113 (2013.01) [A61K 31/7088 (2013.01); A61K 35/30 (2013.01); A61K 38/1716 (2013.01); C12N 5/0623 (2013.01); C12N 2310/14 (2013.01); C12N 2320/32 (2013.01); C12N 2510/00 (2013.01)] | 7 Claims |
1. A method of increasing the functionality of a GABAergic interneuron in the hilus of the hippocampus of an individual having at least one apolipoprotein E4 (apoE4) allele, the method comprising administering to the individual a tau-specific interfering nucleic acid that binds to a tau target and reduces the level of a tau polypeptide in the GABAergic interneuron, wherein the tau target is a contiguous stretch of at least 10 nucleotides of 5596-5807 of SEQ ID NO:2, wherein the tau-specific interfering nucleic acid is coupled to a carrier molecule that provides targeted delivery of the tau-specific interfering nucleic acid to the GABAergic interneuron.
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