CPC C07K 14/4711 (2013.01) [A61K 9/127 (2013.01); A61K 9/1271 (2013.01); A61K 38/1709 (2013.01); A61K 39/0007 (2013.01); A61K 39/39 (2013.01); A61P 25/28 (2018.01); A61K 2039/55516 (2013.01); A61K 2039/55555 (2013.01); A61K 2039/55561 (2013.01); A61K 2039/55572 (2013.01); A61K 2039/6018 (2013.01); A61K 2039/627 (2013.01)] | 24 Claims |
1. A liposome, comprising:
a. a tau peptide having an amino acid sequence selected from the group consisting of SEQ ID NOs: 2, 5, 9, and 12, wherein the tau peptide is presented on the surface of the liposome;
b. a helper T cell epitope comprising at least one amino acid sequence selected from the group consisting of: SEQ ID NOs:23, 24, 25, and 26;
c. a lipidated CpG oligonucleotide, wherein the CpG oligonucleotide comprises one or more phosphorothioate internucleotide linkages, and wherein the CpG oligonucleotide is covalently linked to at least one cholesterol via a linker; and
d. monophosphoryl lipid A (MPLA).
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