US 11,958,869 B2
Ruthenium arene Schiff-base complexes and uses thereof
Maria Babak, Hong Kong (HK); Wee Han Ang, Singapore (SG); and Mun Juinn Chow, Singapore (SG)
Assigned to CITY UNIVERSITY OF HONG KONG, Kowloon (HK)
Filed by CITY UNIVERSITY OF HONG KONG, Kowloon (HK); and NATIONAL UNIVERSITY OF SINGAPORE, Singapore (SG)
Filed on Apr. 13, 2022, as Appl. No. 17/720,110.
Claims priority of provisional application 63/174,425, filed on Apr. 13, 2021.
Prior Publication US 2022/0348601 A1, Nov. 3, 2022
Int. Cl. A61P 35/00 (2006.01); C07F 15/00 (2006.01)
CPC C07F 15/0046 (2013.01) [A61P 35/00 (2018.01)] 9 Claims
 
1. A compound of formula (I), a solvate or a stereoisomer thereof,

OG Complex Work Unit Chemistry
wherein,
R1, R3, and R5 are independently H;
R2, R4, and R6 are independently isopropyl;
R7, R8, R9, R10, R11, and R12 are independently H, alkyl, alkoxyl, or halo;
R13, R14, and R17 are independently H, alkyl, alkoxyl, hydroxy, halo, —C(═NH)NH2, —SO3H, —SO2NH2, —NR′R″, or —CONH2;
R15 is H, hydroxy, halo, —C(═NH)NH2, —SO3H, —SO2NH2, or —CONH2;
R16 is H, alkyl, alkoxyl, hydroxy, —C(═NH)NH2, —SO3H, —SO2NH2—, —NR′R″, or —CONH2;
R13 and R14 are taken together to form a benzene ring, while R15, R16, and R17 are independently H, alkyl, alkoxyl, hydroxy, halo, —C(═NH)NH2, —SO3H, —SO2NH2, —NR′R″, or —CONH2; or
R14 and R15 are taken together to form a benzene ring, while R13, R16, and R17 are independently H, alkyl, alkoxyl, hydroxy, halo, —C(═NH)NH2, —SO3H, —SO2NH2, —NR′R″, or —CONH2;
R′ and R″ are independently H or alkyl;
the alkyl is optionally substituted with one or more halo or hydroxy; and
Y is a counter anion.