CPC C07D 213/75 (2013.01) [A61K 9/2013 (2013.01); A61K 9/2018 (2013.01); A61K 9/2054 (2013.01); A61K 31/496 (2013.01); A61K 47/38 (2013.01)] | 5 Claims |
1. A method of preparing omecamtiv mecarbil dihydrochloride hydrate
comprising:
step (a) admixing methyl 4-(3-amino-2-fluorobenzyl)piperazine-1-carboxylate (Piperazine Aniline)
and phenyl (6-methylpyridin-3-yl)carbamate (Phenyl Carbamate·HCl)
in the presence of diisopropylethylamine and THF to form a solution of omecamtiv mecarbil free base;
step (b) swapping solvent of the solution of omecamtiv mecarbil free base to 2-propanol;
step (c) admixing the solution of omecamtiv mecarbil free base with hydrochloric acid in the presence of water to form omecamtiv mecarbil dihydrochloride hydrate.
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