US 11,958,049 B2
Sample loading cartridge
Johan Öhman, Uppsala (SE); Martin Lovmar, Mölndal (SE); Lovisa Söderberg, Stockholm (SE); and Mikael Olsson, Uppsala (SE)
Assigned to ASTREGO DIAGNOSTICS AB, Uppsala (SE)
Appl. No. 17/276,167
Filed by ASTREGO DIAGNOSTICS AB, Uppsala (SE)
PCT Filed Sep. 20, 2019, PCT No. PCT/SE2019/050894
§ 371(c)(1), (2) Date Mar. 15, 2021,
PCT Pub. No. WO2020/060475, PCT Pub. Date Mar. 26, 2020.
Claims priority of application No. 1851117-0 (SE), filed on Sep. 20, 2018.
Prior Publication US 2022/0032302 A1, Feb. 3, 2022
Int. Cl. B01L 3/00 (2006.01); B81B 1/00 (2006.01); G01N 35/10 (2006.01)
CPC B01L 3/502746 (2013.01) [B01L 3/50273 (2013.01); B81B 1/006 (2013.01); G01N 35/1011 (2013.01); B01L 2200/0621 (2013.01); B01L 2300/02 (2013.01); B01L 2300/0645 (2013.01); B01L 2300/0848 (2013.01); B01L 2300/087 (2013.01); B01L 2400/0487 (2013.01); B81B 2201/057 (2013.01); B81B 2203/0338 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A sample loading cartridge for a microfluidic device, the sample loading cartridge comprising:
a cartridge body comprising a sample reservoir configured to house a volume of a liquid sample;
a sample port in connection with the sample reservoir and configured to receive the liquid sample;
an output channel connected to and extending from the sample reservoir; and
a feedback channel connected to the sample reservoir and to the sample port and configured to vent air through the feedback channel as the sample reservoir is filled with liquid sample received from the sample port, wherein
the cartridge body comprises a detection portion aligned with at least a portion of the feedback channel to enable detection of presence of liquid sample in the feedback channel; and
a flow resistance of the feedback channel is lower than a flow resistance of the output channel to cause the liquid sample received from the sample port to enter the feedback channel when the sample reservoir is full with liquid sample, with substantially no liquid sample entering the output channel.