US 11,957,880 B2
Auto injector with reconstitution handling support
Steen Jensen, Dragør (DK); Henrik Egesborg, Hellerup (DK); Bjørn Knud Andersen, Struer (DK); Martin Nørgaard Larsen, Viborg (DK); and Johnny Elkjær, Struer (DK)
Assigned to Ascendis Pharma A/S, Hellerup (DK)
Appl. No. 16/608,115
Filed by Ascendis Pharma A/S, Hellerup (DK)
PCT Filed Jun. 29, 2018, PCT No. PCT/EP2018/067532
§ 371(c)(1), (2) Date Oct. 24, 2019,
PCT Pub. No. WO2019/002534, PCT Pub. Date Jan. 3, 2019.
Claims priority of application No. 17178728 (EP), filed on Jun. 29, 2017; and application No. 17179545 (EP), filed on Jul. 4, 2017.
Prior Publication US 2023/0090661 A1, Mar. 23, 2023
Int. Cl. A61M 5/24 (2006.01); A61M 5/20 (2006.01); A61M 5/31 (2006.01); A61M 5/44 (2006.01)
CPC A61M 5/2448 (2013.01) [A61M 5/20 (2013.01); A61M 5/3146 (2013.01); A61M 5/44 (2013.01); A61M 2205/50 (2013.01); A61M 2205/581 (2013.01); A61M 2205/583 (2013.01); A61M 2205/6063 (2013.01)] 25 Claims
OG exemplary drawing
 
1. An auto injector for administering a medicament, the auto injector comprising:
a housing;
a cartridge receiver configured to receive a cartridge comprising a first stopper, a second stopper, and a cartridge compartment containing the medicament, the cartridge compartment having a first cartridge subcompartment containing a first medicament component of the medicament and a second cartridge subcompartment containing a second medicament component of the medicament, the cartridge further comprising a bypass section providing fluid communication between the first cartridge subcompartment and the second cartridge subcompartment;
an orientation sensor configured to detect an orientation of the cartridge or an orientation of the auto injector or both;
a drive module coupled to move a plunger rod between a retracted plunger rod position and an extended plunger rod position, the plunger rod being configured to move the first stopper; and
a processing unit coupled to the drive module, wherein the processing unit is configured to:
control the drive module to move the plunger rod from a first plunger rod position to a mix plunger rod position with a mix plunger rod speed, wherein the mix plunger rod position is selected to position the first stopper in a position wherein the first medicament component is mixed with the second medicament component; and
provide an onset signal after a number of completed inversions of the auto injector has been performed;
wherein the cartridge receiver is configured to receive a cartridge assembly comprising the cartridge and a cartridge code feature, and the auto injector comprising a code sensor configured to read the cartridge code feature, and wherein the processing unit is coupled to the code sensor and further configured to receive from the code sensor a code signal indicative of the cartridge code feature, wherein the cartridge code feature defines the number of completed inversions required for the medicament in the cartridge.