US 11,957,757 B2
Method for preparing stabilized metal ion ligand nanocomplex and compositions thereof
Feng Li, Auburn, AL (US); Wu Chen, Auburn, AL (US); and Pengyu Chen, Auburn, AL (US)
Assigned to AUBURN UNIVERSITY, Auburn, AL (US)
Filed by AUBURN UNIVERSITY, Auburn, AL (US)
Filed on May 24, 2021, as Appl. No. 17/328,282.
Application 17/328,282 is a continuation of application No. 16/222,500, filed on Dec. 17, 2018, granted, now 11,045,553.
Claims priority of provisional application 62/607,086, filed on Dec. 18, 2017.
Prior Publication US 2021/0275676 A1, Sep. 9, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 47/52 (2017.01); A61K 31/325 (2006.01); A61K 31/337 (2006.01); A61K 31/704 (2006.01); A61K 33/24 (2019.01); A61K 33/242 (2019.01); A61K 33/243 (2019.01); A61K 33/244 (2019.01); A61K 47/69 (2017.01); A61K 49/18 (2006.01); C07F 1/08 (2006.01)
CPC A61K 47/52 (2017.08) [A61K 31/325 (2013.01); A61K 31/337 (2013.01); A61K 31/704 (2013.01); A61K 33/24 (2013.01); A61K 33/242 (2019.01); A61K 33/243 (2019.01); A61K 33/244 (2019.01); A61K 47/6923 (2017.08); A61K 49/1824 (2013.01); C07F 1/08 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A method of making a nanoparticle complex, said method comprising the steps of:
providing a first composition, wherein the first composition comprises at least one ligand and at least one stabilizer;
providing a second composition, wherein the second composition comprises a salt of the formula MnXy and at least one stabilizer,
wherein M is a metal cation and X is counterion, and
wherein n is an integer from 1 to 3 and y is an integer from 1 to 5; and
combining the first composition and the second composition to obtain the nanoparticle complex, wherein the nanoparticle complex comprises the ligand and M,
wherein the method further comprises a step of providing a third composition comprising one or more stabilizers, and wherein the combining of the first composition and the second composition is performed prior to combination with the third composition.