US 11,957,123 B2
Functionalized kit for preparing hydrogels
Elisabeth Kommisrud, Stange (NO); Anne Hege Alm-Kristiansen, Vang på Hedmarken (NO); Geir Klinkenberg, Heimdal (NO); Lars Kilaas, Trondheim (NO); Wilhelm Robert Glomm, Malvik (NO); Eugenia Mariana Sandru, Trondheim (NO); and Heidi Johnsen, Trondheim (NO)
Assigned to SpermVital AS, Hamar (NO)
Appl. No. 17/058,232
Filed by SpermVital AS, Hamar (NO)
PCT Filed Jun. 4, 2019, PCT No. PCT/EP2019/064468
§ 371(c)(1), (2) Date Nov. 24, 2020,
PCT Pub. No. WO2019/234010, PCT Pub. Date Dec. 12, 2019.
Claims priority of application No. 20180768 (NO), filed on Jun. 4, 2018.
Prior Publication US 2021/0186008 A1, Jun. 24, 2021
Int. Cl. A61D 19/02 (2006.01); A01N 1/02 (2006.01)
CPC A01N 1/0231 (2013.01) [A01N 1/0226 (2013.01); A01N 1/0268 (2013.01); A61D 19/024 (2013.01)] 31 Claims
OG exemplary drawing
 
1. A kit for preparing a sustained release composition, the kit comprising a first container and a second container; the first container comprising an activator composition and either a first diffusion barrier or a second diffusion barrier; the second container comprising an ionically crosslinkable biocompatible polymer, an inactive crosslinker and optionally a material to be released; the first and/or second diffusion barrier allowing the activator composition and the inactive crosslinker to come in contact with each other at a delayed rate to provide an active crosslinker thereby ensuring delayed and sustained release of the active crosslinker;
wherein
the first container and/or the second container are of a size and form which allows the ionically crosslinkable biocompatible polymer to come into contact with the active crosslinker throughout the first container and/or the second container thereby ensuring that there is crosslinked biocompatible polymer throughout the first container and/or the second container;
the ionically crosslinkable biocompatible polymer is a divalent cation crosslinkable biocompatible polymer;
the term “active crosslinker” refers to ions suitable for crosslinking the ionically crosslinkable biocompatible polymer;
the term “inactive crosslinker” refers to a compound that requires activation by the activator composition in order to be able to release ions for crosslinking the ionically crosslinkable biocompatible polymer;
and
wherein the first container comprises the first diffusion barrier; the activator composition in admixture with the first diffusion barrier is coated on an inner surface of the first container;
wherein the first container comprises the first diffusion barrier; the activator composition and the first diffusion barrier are coated on the inner surface of the first container in separate layers thereby forming an inner surface layer and an intermediate layer, the intermediate layer comprising the activator composition;
wherein the first container comprises the second diffusion barrier and is made from a first polymer material; i) the activator composition, ii) the activator composition embedded or encapsulated within a second polymer material, or iii) a mixture of i) and ii) being extruded into the first polymer material during production of the first container; the second diffusion barrier being the first polymer material, the second polymer material or a combination thereof; or
wherein the first container comprises the second diffusion barrier and is made from a first polymer material; a third polymer material in admixture with i) the activator composition, ii) the activator composition embedded or encapsulated within a second polymer material, or iii) a mixture of i) and ii) being co-extruded with the first polymer material during production of the first container thereby forming an inner surface layer and an outer surface layer, the inner surface layer comprising the activator composition; and the second diffusion barrier being the second polymer material, the third polymer material or a combination thereof.