US 12,278,098 B2
High resolution imaging apparatus and method
Paul Corkum, Ottawa (CA); and Alexander V. Loboda, Thornhill (CA)
Assigned to STANDARD BIOTOOLS CANADA INC., Markham (CA); and UNIVERSITY OF OTTAWA, Ottawa (CA)
Filed by Standard BioTools Canada Inc., Markham (CA); and University of Ottawa, Ottawa (CA)
Filed on Mar. 20, 2024, as Appl. No. 18/610,570.
Application 18/610,570 is a continuation of application No. 17/580,917, filed on Jan. 21, 2022, granted, now 11,967,496.
Application 17/580,917 is a continuation of application No. 17/253,538, granted, now 11,264,221, issued on Mar. 1, 2022, previously published as PCT/US2019/037644, filed on Jun. 18, 2019.
Claims priority of provisional application 62/792,759, filed on Jan. 15, 2019.
Claims priority of provisional application 62/686,341, filed on Jun. 18, 2018.
Prior Publication US 2024/0371622 A1, Nov. 7, 2024
Int. Cl. H01J 49/04 (2006.01); G01N 33/68 (2006.01); G02B 21/33 (2006.01); H01J 37/20 (2006.01); H01J 37/28 (2006.01); H01J 49/00 (2006.01); H01J 49/02 (2006.01); H01J 49/06 (2006.01); H01J 49/10 (2006.01); H01J 49/14 (2006.01); H01J 49/16 (2006.01); H01J 49/40 (2006.01)
CPC H01J 49/0463 (2013.01) [G01N 33/6848 (2013.01); G01N 33/6851 (2013.01); G02B 21/33 (2013.01); H01J 37/20 (2013.01); H01J 37/28 (2013.01); H01J 49/0004 (2013.01); H01J 49/0031 (2013.01); H01J 49/025 (2013.01); H01J 49/0418 (2013.01); H01J 49/067 (2013.01); H01J 49/105 (2013.01); H01J 49/142 (2013.01); H01J 49/161 (2013.01); H01J 49/164 (2013.01); H01J 49/40 (2013.01)] 5 Claims
OG exemplary drawing
 
1. A method of analysing a biological sample comprising:
staining the biological sample with a contrast agent for electron microscopy,
labelling the sample with labelling atoms,
imaging the biological sample by electron microscopy,
directing a beam of radiation emitted by the laser source towards a location on the biological sample to produce an ablated plume of sample material;
ionising the ablated plume of sample material; and
detecting the sample ions from the sample material.