US 12,278,013 B2
Device and method for determining a level or concentration of an analyte in a person's blood from one or more volatile analytes in the person's breath
Sudhir Shrestha, Rohnert Park, CA (US)
Assigned to SONOMA STATE UNIVERSITY, Rohnert Park, CA (US)
Filed by Sudhir Shrestha, Rohnert Park, CA (US)
Filed on Oct. 22, 2021, as Appl. No. 17/508,877.
Claims priority of provisional application 63/109,323, filed on Nov. 3, 2020.
Prior Publication US 2022/0139557 A1, May 5, 2022
Int. Cl. G16H 50/20 (2018.01); A61B 5/00 (2006.01); A61B 5/08 (2006.01); A61B 5/097 (2006.01); G06N 3/08 (2023.01); G06N 20/10 (2019.01)
CPC G16H 50/20 (2018.01) [A61B 5/0004 (2013.01); A61B 5/082 (2013.01); A61B 5/097 (2013.01); A61B 5/7246 (2013.01); A61B 5/7267 (2013.01); G06N 3/08 (2013.01); G06N 20/10 (2019.01)] 20 Claims
OG exemplary drawing
 
1. A device, comprising:
one or more metal oxide semiconductor (MOS) sensors configured to detect one or more volatile analytes in a person's breath and provide a parametric value representing a level or concentration of the one or more volatile analytes in the person's breath;
a support vector machine or artificial neural network that correlates the parametric value with known levels or concentrations of a disease-related analyte in the person's blood:
a microcontroller in communication with each of the one or more sensors, configured to receive the parametric value from each of the one or more sensors and execute the support vector machine or artificial neural network, the microcontroller containing logic adapted to correlate (i) the parametric value from the one or more sensors to the level or concentration of the disease-related analyte in the person's blood and/or (ii) the level or concentration of the one or more volatile analytes in the person's breath to the level or concentration of the disease-related analyte in the person's blood;
a transmitter configured to transmit at least one of the parametric value from each of the one or more sensors, the level or concentration of the one or more volatile analytes in the person breath, and/or the level or concentration of a disease-related analyte in the person's blood to at least one of an external processing device and a display;
a battery configured to provide electrical power to the one or more sensors, the microcontroller, and the transmitter; and
a housing that surrounds and/or encloses the one or more sensors, the microcontroller, the transmitter and the battery, or at least secures the one or more sensors, the microcontroller, the transmitter and the battery in place relative to one another, the housing containing or securing a tube or opening through which the person exhales so that the person's breath contacts the one or more sensors for a predetermined minimum period of time.