US 12,277,866 B2
Organosynthetic dynamic heart model
Clara Park, Cambridge, MA (US); Xuanhe Zhao, Cambridge, MA (US); Hyunwoo Yuk, Cambridge, MA (US); Christopher Tam Nguyen, Cambridge, MA (US); and Ellen T. Roche, Cambridge, MA (US)
Assigned to MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA (US); and THE GENERAL HOSPITAL CORPORATION, Boston, MA (US)
Filed by Massachusetts Institute of Technology, Cambridge, MA (US); and The General Hospital Corporation, Boston, MA (US)
Filed on Mar. 5, 2021, as Appl. No. 17/193,910.
Claims priority of provisional application 63/021,014, filed on May 6, 2020.
Prior Publication US 2021/0350725 A1, Nov. 11, 2021
Int. Cl. G09B 23/30 (2006.01); G09B 23/32 (2006.01); B33Y 80/00 (2015.01); G01N 3/08 (2006.01); G01N 3/32 (2006.01)
CPC G09B 23/306 (2013.01) [G09B 23/30 (2013.01); G09B 23/32 (2013.01); B33Y 80/00 (2014.12); G01N 3/08 (2013.01); G01N 3/32 (2013.01); G01N 2203/0005 (2013.01); G01N 2203/0017 (2013.01); G01N 2203/0062 (2013.01); G01N 2203/0091 (2013.01)] 34 Claims
OG exemplary drawing
 
1. A biohybrid heart comprising
organic endocardial tissue scaffold comprising one or more intact intracardiac structures from an explanted heart, and
synthetic myocardium,
wherein the endocardial tissue scaffold and synthetic myocardium is combined to form an explanted heart with myocardial tissue and one or more intact intracardiac structures and passive or active synthetic myocardium.