US 12,277,719 B2
Multispectral microscope system and method for registering first and second images by means thereof
Christian Schumann, Lich (DE); Kai Ritschel, Heuchelheim (DE); and Mate Beljan, Oberursel (DE)
Assigned to LEICA MICROSYSTEMS CMS GMBH, Wetzlar (DE)
Filed by Leica Microsystems CMS GmbH, Wetzlar (DE)
Filed on Feb. 21, 2022, as Appl. No. 17/676,318.
Claims priority of application No. 21161036 (EP), filed on Mar. 5, 2021.
Prior Publication US 2022/0284604 A1, Sep. 8, 2022
Int. Cl. G06T 7/32 (2017.01); G02B 21/16 (2006.01); G02B 21/36 (2006.01); G06T 5/80 (2024.01)
CPC G06T 7/32 (2017.01) [G02B 21/16 (2013.01); G02B 21/365 (2013.01); G06T 5/80 (2024.01); G06T 2207/10056 (2013.01); G06T 2207/10064 (2013.01); G06T 2207/20212 (2013.01); G06T 2207/30108 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A multispectral microscope system, comprising:
a base plate;
a first detector element comprising a first detector array and configured to capture a first image of a sample in a first spectral channel;
at least a second detector element comprising a second detector array different from the first detector array and configured to capture a second image of the sample in a second spectral channel, wherein the first detector element and the second detector element are mounted on the base plate and are offset from each other with a distance; and
a processor configured to determine a spatial correlation between the first and second images based on a spectral crosstalk between the first and second spectral channels, and to register the first and second images based on the spatial correlation, so as to compensate for a change of the distance between the first detector element and the second detector element caused by thermal expansion of the base plate.