	US 12,276,665 B2
	Methods for screening and identifying agents that inhibit or modulate the nuclear egress complex of herpesviruses
Manfred Marschall, Nuremberg (DE); Yves Muller, Erlangen (DE); Heinrich Sticht, Furth (DE); and Jutta Eichler, Erlangen (DE)
Assigned to AICURIS ANTI-INFECTIVE CURES AG, Wuppertal (DE)
Appl. No. 17/261,501
Filed by AICURIS GMBH & CO. KG, Wuppertal (DE); and FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN-NURNBERG, Erlangen (DE)
PCT Filed Jul. 19, 2019, PCT No. PCT/EP2019/069562 § 371(c)(1), (2) Date Jan. 19, 2021, PCT Pub. No. WO2020/016433, PCT Pub. Date Jan. 23, 2020.
Claims priority of application No. 18184806 (EP), filed on Jul. 20, 2018.
Prior Publication US 2021/0396761 A1, Dec. 23, 2021
Int. Cl. G01N 33/68 (2006.01); C07K 14/04 (2006.01); C07K 14/05 (2006.01)

CPC G01N 33/6803 (2013.01) [C07K 14/04 (2013.01); C07K 14/05 (2013.01); G01N 2333/04 (2013.01); G01N 2333/05 (2013.01)]

21 Claims

1. A polypeptide comprising at least two fused domains, wherein

a) a first domain comprises a polypeptide comprising amino acid residues 1 to 171 according to SEQ ID NO: 1 or according to SEQ ID NO: 2, or a homologue thereof, and wherein a second domain comprises a polypeptide comprising amino acid residues 180 to 413 according to SEQ ID NO: 1 or amino acid residues 180 to 208 according to SEQ ID NO: 2, or a homologue thereof;

b) a first domain comprises a polypeptide comprising amino acid residues 1 to 192 according to SEQ ID NO: 3 or according to SEQ ID NO: 4, or a homologue thereof, and wherein a second domain comprises a polypeptide comprising amino acid residues 198 to 438 according to SEQ ID NO: 3 or amino acid residues 198 to 230 according to SEQ ID NO: 4, or a homologue thereof;

c) a first domain comprises a polypeptide comprising amino acid residues 1 to 174 according to SEQ ID NO: 5 or according to SEQ ID NO: 6, or a homologue thereof, and wherein a second domain comprises a polypeptide comprising amino acid residues 183 to 439 according to SEQ ID NO: 5 or amino acid residues 183 to 215 according to SEQ ID NO: 6, or a homologue thereof.