US 12,275,982 B2
Devices, systems and methods to detect viable infectious agents in a fluid sample and susceptibility of infectious agents to anti-infectives
Oren S. Knopfmacher, San Francisco, CA (US); Meike Herget, Woodside, CA (US); Michael D. Laufer, Menlo Park, CA (US); and August Estabrook, South San Francisco, CA (US)
Assigned to Avails Medical, Inc., Menlo Park, CA (US)
Filed by Avails Medical, Inc., Menlo Park, CA (US)
Filed on Jan. 25, 2024, as Appl. No. 18/423,077.
Application 18/423,077 is a continuation of application No. 17/242,810, filed on Apr. 28, 2021, granted, now 11,913,058.
Application 17/242,810 is a continuation of application No. 16/241,691, filed on Jan. 7, 2019, granted, now 11,021,732, issued on Jun. 1, 2021.
Application 16/241,691 is a continuation of application No. 15/482,307, filed on Apr. 7, 2017, granted, now 10,174,356, issued on Jan. 8, 2019.
Claims priority of provisional application 62/343,564, filed on May 31, 2016.
Prior Publication US 2024/0158828 A1, May 16, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C12Q 1/18 (2006.01); C12Q 1/00 (2006.01); C12Q 1/02 (2006.01); C12Q 1/04 (2006.01); G01N 27/27 (2006.01); G01N 27/327 (2006.01); G01N 33/50 (2006.01); B01L 3/00 (2006.01)
CPC C12Q 1/18 (2013.01) [C12Q 1/006 (2013.01); C12Q 1/025 (2013.01); C12Q 1/04 (2013.01); G01N 27/27 (2013.01); G01N 27/3273 (2013.01); G01N 27/3275 (2013.01); G01N 33/5011 (2013.01); B01L 3/502715 (2013.01); G01N 27/3272 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of assessing a susceptibility of an infectious agent to an anti-infective, the method comprising:
introducing a fluid sample to a first container or vessel and a second container or vessel;
introducing a first solution to the first container or vessel;
introducing a second solution to the second container or vessel, wherein at least one of the second container or vessel and the second solution comprises an anti-infective;
monitoring a first electrical characteristic of a first sensing device exposed to the first solution;
monitoring a second electrical characteristic of a second sensing device exposed to the second solution; and
comparing the first electrical characteristic with the second electrical characteristic, wherein any differences between the first electrical characteristic and the second electrical characteristic, or lack thereof, is used to assess the susceptibility of the infectious agent to the anti-infective.