US 12,275,930 B2
Disposable cartridge cooperating with a platform for a system and installation for monitoring and controlling fluids
David Horna Tomás, Hertfordshire (GB); Miquel Costa Ferrando, Hertfordshire (GB); Jorge Aranda Hernández, Hertfordshire (GB); Mireia Ruiz Maymó, Hertfordshire (GB); and Carlos Julià Figueras, Hertfordshire (GB)
Assigned to AGLARIS LTD, Hertfordshire (GB)
Appl. No. 17/048,740
Filed by AGLARIS LTD, Hertfordshire (GB)
PCT Filed Apr. 17, 2019, PCT No. PCT/EP2019/059979
§ 371(c)(1), (2) Date Oct. 19, 2020,
PCT Pub. No. WO2019/202024, PCT Pub. Date Oct. 24, 2019.
Claims priority of application No. 18168268 (EP), filed on Apr. 19, 2018.
Prior Publication US 2021/0261904 A1, Aug. 26, 2021
Int. Cl. C12M 1/36 (2006.01); C12M 1/00 (2006.01); C12M 1/34 (2006.01); C12M 3/00 (2006.01)
CPC C12M 41/48 (2013.01) [C12M 23/28 (2013.01); C12M 23/42 (2013.01); C12M 41/26 (2013.01); C12M 41/32 (2013.01); C12M 41/34 (2013.01); C12M 41/46 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A disposable cartridge configured for cooperating with a platform for monitoring and controlling the state of at least a cell culture located within a cell culture chamber arranged outside the disposable cartridge, characterized in that it comprises:
a duct network comprising at least one fluid inlet and fluid outlet through which said duct network is configured to be in fluid communication with the interior of the cell culture chamber, this duct network being configured for circulating at least one fluid therein,
a first sensor connected to the duct network, the first sensor being configured for measuring at least a first fluid parameter,
a second sensor connected to the duct network, the second sensor being configured for measuring at least a second fluid parameter regardless of the first sensor, the second fluid parameter being different from the first fluid parameter, and
flow control means for selectively controlling the flow of fluid circulating through the duct network towards the first sensor or the second sensor or both the first and second sensors, wherein
the first sensor and second sensor are respectively configured for connecting with at least one processing means of the platform so that both first and second sensor control the state of at least one fluid coming from the cell culture chamber and circulating through the duct network,
the fluid to be circulated in the duct network is a medium, or cells suspended in a medium, or a sample of any of the above, and the medium is a liquid medium and/or a culture medium,
the disposable cartridge is configured to be directly connected with the cell culture chamber through an outlet duct connected to the fluid inlet and an inlet duct connected to the fluid outlet,
the duct network comprises a first duct arranged between the fluid inlet and the fluid outlet, and a second duct configured for being in fluid communication with the fluid inlet, and
the first sensor is connected to the first duct, and the second sensor is connected to the second duct.