US 12,275,830 B2
Sustained-release antibacterial film and preparation method thereof
Tian Ding, Zhejiang (CN); Mofei Shen, Zhejiang (CN); Donghong Liu, Zhejiang (CN); Wei Zhao, Zhejiang (CN); and Jinsong Feng, Zhejiang (CN)
Assigned to ZHEJIANG UNIVERSITY, (CN); and JIANGNAN UNIVERSITY, (CN)
Appl. No. 17/909,285
Filed by ZHEJIANG UNIVERSITY, Zhejiang (CN); and JIANGNAN UNIVERSITY, Jiangsu (CN)
PCT Filed Mar. 11, 2022, PCT No. PCT/CN2022/080307
§ 371(c)(1), (2) Date Sep. 2, 2022,
PCT Pub. No. WO2023/082508, PCT Pub. Date May 19, 2023.
Claims priority of application No. 202111326576.3 (CN), filed on Nov. 10, 2021.
Prior Publication US 2024/0199826 A1, Jun. 20, 2024
Int. Cl. C08J 5/18 (2006.01); C08K 3/08 (2006.01); C08K 5/13 (2006.01)
CPC C08J 5/18 (2013.01) [C08K 5/13 (2013.01); C08J 2383/04 (2013.01); C08J 2405/16 (2013.01); C08K 2003/0806 (2013.01); C08K 2201/011 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A method for preparing a sustained-release antibacterial film, comprising the following steps:
(1) mixing a cyclodextrin metal-organic framework (CD-MOF) material with a silver nitrate short-chain alcohol solution to prepare a nano-silver-loaded CD-MOF material, which is recorded as an intermediate material A;
(2) mixing the intermediate material A with a caffeic acid short-chain alcohol solution to prepare a CD-MOF material loaded with nano-silver and caffeic acid, which is recorded as an intermediate material B;
(3) dispersing the intermediate material B in a solvent, adding a polydimethylsiloxane (PDMS) prepolymer, adding a PDMS crosslinking agent after the prepolymer, and mixing by stirring for 8 h to 11 h to obtain a casting solution; and
(4) coating the casting solution on a film support material, conducting vacuum drying, and peeling off a film from the film support material to obtain the sustained-release antibacterial film; wherein
the short-chain alcohol is anhydrous methanol or anhydrous ethanol.