	US 12,275,803 B2
	Functionalization of biopolymers with growth factor-binding peptides
João Francisco Ribeiro Pereira Simões Crispim, Eindhoven (NL); Pascal Jonkheijm, Manderveen (NL); and Daniël Bart Frederik Saris, Rochester, MN (US)
Assigned to Universiteit Twente, Enschede (NL)
Appl. No. 16/465,524
Filed by Universiteit Twente, Enschede (NL)
PCT Filed Nov. 30, 2017, PCT No. PCT/NL2017/050800 § 371(c)(1), (2) Date May 30, 2019, PCT Pub. No. WO2018/101826, PCT Pub. Date Jun. 7, 2018.
Claims priority of application No. 2017900 (NL), filed on Nov. 30, 2016.
Prior Publication US 2020/0095341 A1, Mar. 26, 2020
Int. Cl. C07K 17/08 (2006.01); A61K 47/59 (2017.01); C07K 14/47 (2006.01); C07K 16/22 (2006.01)

CPC C07K 17/08 (2013.01) [A61K 47/593 (2017.08); C07K 14/47 (2013.01); C07K 16/22 (2013.01)]

14 Claims

1. A biopolymer that is functionalized with a peptide,

wherein the biopolymer is a synthetic polyester,

wherein the peptide comprises KGLPLGNSH (SEQ ID NO:3), wherein the number of amino acid residues in the peptide is up to 50; and

wherein the peptide is coupled to a carbonyl group of the non-functionalized biopolymer through binding of an N-terminal amino group of the peptide, or through binding of an amino group in a side chain of the N-terminal lysine of the peptide.