	US 12,275,781 B2
	Monoclonal antibodies against MHC-bound human dickkopf-1 peptides and uses thereof
Qing Yi, Houston, TX (US); and Jianfei Qian, Houston, TX (US)
Assigned to BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Appl. No. 17/425,564
Filed by Board of Regents, The University of Texas System, Austin, TX (US)
PCT Filed Feb. 3, 2020, PCT No. PCT/US2020/016364 § 371(c)(1), (2) Date Jul. 23, 2021, PCT Pub. No. WO2020/160532, PCT Pub. Date Aug. 6, 2020.
Claims priority of provisional application 62/800,007, filed on Feb. 1, 2019.
Prior Publication US 2022/0089707 A1, Mar. 24, 2022
Int. Cl. C07K 16/18 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01)

CPC C07K 16/18 (2013.01) [A61P 35/00 (2018.01); A61K 2039/505 (2013.01); C07K 2317/32 (2013.01); C07K 2317/565 (2013.01); C07K 2317/732 (2013.01); C07K 2317/734 (2013.01)]

22 Claims

1. A monoclonal antibody or antibody fragment, wherein the antibody or antibody fragment comprises:

a heavy chain variable region (VH) comprising a VHCDR1 amino acid sequence of SEQ ID NO: 2, a VHCDR2 amino acid sequence of SEQ ID NO: 3, and a VHCDR3 amino acid sequence of SEQ ID NO: 4; and a light chain variable region (VL) comprising a VLCDR1 amino acid sequence of SEQ ID NO: 5, a VLCDR2 amino acid sequence of SEQ ID NO: 6, and a VLCDR3 amino acid sequence of SEQ ID NO: 7.